Abstract
Colorectal cancer progression originates when accumulated genetic and epigenetic alterations cause genomic instability and a malignant phenotype. Subsequent molecular pathway deregulation leads to histopathologic changes that are clinically evident as aberrant crypt foci (ACF) and visualized by high-magnification chromoscopic colonoscopy. ACF are biomarkers of increased colorectal cancer risk, particularly those with dysplastic features. Genetic profiling using genomic instability, loss of heterozygosity, and methylation analysis has revealed a minority population of ACF genotypically analogous to cancer.
Original language | English (US) |
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Pages (from-to) | 207-213 |
Number of pages | 7 |
Journal | Journal of surgical oncology |
Volume | 98 |
Issue number | 3 |
DOIs | |
State | Published - Sep 1 2008 |
Keywords
- Colonoscopy
- Colorectal
- Crypt
- Gene
- Methylation
ASJC Scopus subject areas
- Surgery
- Oncology