Aberrant expression of HOX genes in oral dysplasia and squamous cell carcinoma tissues

Nur Mohammad Monsur Hassan; Jun Ichi Hamada; Taichi Murai; Akihusa Seino; Yoko Takahashi; Mitsuhiro Tada; Xiuru Zhang; Haruhiko Kashiwazaki; Yutaka Yamazaki; Nobuo Inoue; Tetsuya Moriuchi

doi:10.3727/000000006783981080

Aberrant expression of HOX genes in oral dysplasia and squamous cell carcinoma tissues

Nur Mohammad Monsur Hassan, Jun Ichi Hamada, Taichi Murai, Akihusa Seino, Yoko Takahashi, Mitsuhiro Tada, Xiuru Zhang, Haruhiko Kashiwazaki, Yutaka Yamazaki, Nobuo Inoue, Tetsuya Moriuchi

Head & Neck Surgery

Research output: Contribution to journal › Article › peer-review

51 Scopus citations

Abstract

Human HOX genes consist of 39 genes and encode transcription factors that function as master developmental regulators. We hypothesized that the misexpression of HOX genes was associated with carcinogenesis and malignant progression. The expression levels of 39 HOX genes in 31 human oral squamous cell carcinoma (SCC), 11 dysplasia, and 10 normal mucosa tissues were quantified by the real-time RT-PCR method. The expression levels of 18 HOX genes in the SCC tissues were significantly higher than those in the normal mucosa tissues. The dysplasia tissues showed higher expression of HOXA2, A3, B3, and D10 than normal mucosa tissues whereas they showed lower expression of HOXA1, B7, B9, and C8 than SCC. The SCC with lymph node metastasis showed high expression of HOXC6 compared to the SCC without it. These results suggest that misexpressions of particular HOX genes are implicated in the development of oral dysplasia and SCC.

Original language	English (US)
Pages (from-to)	217-224
Number of pages	8
Journal	Oncology research
Volume	16
Issue number	5
DOIs	https://doi.org/10.3727/000000006783981080
State	Published - 2006

Keywords

Dysplasia
HOX
Metastasis
Oral mucosa
Oral squamous carcinoma

ASJC Scopus subject areas

Oncology
Cancer Research

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10.3727/000000006783981080

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title = "Aberrant expression of HOX genes in oral dysplasia and squamous cell carcinoma tissues",

abstract = "Human HOX genes consist of 39 genes and encode transcription factors that function as master developmental regulators. We hypothesized that the misexpression of HOX genes was associated with carcinogenesis and malignant progression. The expression levels of 39 HOX genes in 31 human oral squamous cell carcinoma (SCC), 11 dysplasia, and 10 normal mucosa tissues were quantified by the real-time RT-PCR method. The expression levels of 18 HOX genes in the SCC tissues were significantly higher than those in the normal mucosa tissues. The dysplasia tissues showed higher expression of HOXA2, A3, B3, and D10 than normal mucosa tissues whereas they showed lower expression of HOXA1, B7, B9, and C8 than SCC. The SCC with lymph node metastasis showed high expression of HOXC6 compared to the SCC without it. These results suggest that misexpressions of particular HOX genes are implicated in the development of oral dysplasia and SCC.",

keywords = "Dysplasia, HOX, Metastasis, Oral mucosa, Oral squamous carcinoma",

author = "Hassan, {Nur Mohammad Monsur} and Hamada, {Jun Ichi} and Taichi Murai and Akihusa Seino and Yoko Takahashi and Mitsuhiro Tada and Xiuru Zhang and Haruhiko Kashiwazaki and Yutaka Yamazaki and Nobuo Inoue and Tetsuya Moriuchi",

year = "2006",

doi = "10.3727/000000006783981080",

language = "English (US)",

volume = "16",

pages = "217--224",

journal = "Oncology research",

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T1 - Aberrant expression of HOX genes in oral dysplasia and squamous cell carcinoma tissues

AU - Hassan, Nur Mohammad Monsur

AU - Hamada, Jun Ichi

AU - Murai, Taichi

AU - Seino, Akihusa

AU - Takahashi, Yoko

AU - Tada, Mitsuhiro

AU - Zhang, Xiuru

AU - Kashiwazaki, Haruhiko

AU - Yamazaki, Yutaka

AU - Inoue, Nobuo

AU - Moriuchi, Tetsuya

PY - 2006

Y1 - 2006

N2 - Human HOX genes consist of 39 genes and encode transcription factors that function as master developmental regulators. We hypothesized that the misexpression of HOX genes was associated with carcinogenesis and malignant progression. The expression levels of 39 HOX genes in 31 human oral squamous cell carcinoma (SCC), 11 dysplasia, and 10 normal mucosa tissues were quantified by the real-time RT-PCR method. The expression levels of 18 HOX genes in the SCC tissues were significantly higher than those in the normal mucosa tissues. The dysplasia tissues showed higher expression of HOXA2, A3, B3, and D10 than normal mucosa tissues whereas they showed lower expression of HOXA1, B7, B9, and C8 than SCC. The SCC with lymph node metastasis showed high expression of HOXC6 compared to the SCC without it. These results suggest that misexpressions of particular HOX genes are implicated in the development of oral dysplasia and SCC.

AB - Human HOX genes consist of 39 genes and encode transcription factors that function as master developmental regulators. We hypothesized that the misexpression of HOX genes was associated with carcinogenesis and malignant progression. The expression levels of 39 HOX genes in 31 human oral squamous cell carcinoma (SCC), 11 dysplasia, and 10 normal mucosa tissues were quantified by the real-time RT-PCR method. The expression levels of 18 HOX genes in the SCC tissues were significantly higher than those in the normal mucosa tissues. The dysplasia tissues showed higher expression of HOXA2, A3, B3, and D10 than normal mucosa tissues whereas they showed lower expression of HOXA1, B7, B9, and C8 than SCC. The SCC with lymph node metastasis showed high expression of HOXC6 compared to the SCC without it. These results suggest that misexpressions of particular HOX genes are implicated in the development of oral dysplasia and SCC.

KW - Dysplasia

KW - HOX

KW - Metastasis

KW - Oral mucosa

KW - Oral squamous carcinoma

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ER -

Aberrant expression of HOX genes in oral dysplasia and squamous cell carcinoma tissues

Abstract

Keywords

ASJC Scopus subject areas

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