TY - JOUR
T1 - Ablation of B7-H3 but not B7-H4 results in highly increased tumor burden in a murine model of spontaneous prostate cancer
AU - Kreymborg, Katharina
AU - Haak, Stefan
AU - Murali, Rajmohan
AU - Wei, Joyce
AU - Waitz, Rebecca
AU - Gasteiger, Georg
AU - Savage, Peter A.
AU - Van Den Brink, Marcel R.M.
AU - Allison, James P.
N1 - Publisher Copyright:
© 2015 AACR.
PY - 2015/8
Y1 - 2015/8
N2 - The costimulatory molecules B7-H3 and B7-H4 are overexpressed in a variety of human tumors and have been hypothesized as possible biomarkers and immunotherapeutic targets. Despite this potential, the predominating uncertainty about their functional implication in tumor-host interaction hampers their evaluation as a target for cancer therapy. By means of a highly physiologic, spontaneous tumor model in mice, we establish a causal link between B7-H3 and host tumor control and found B7-H4 to be redundant.
AB - The costimulatory molecules B7-H3 and B7-H4 are overexpressed in a variety of human tumors and have been hypothesized as possible biomarkers and immunotherapeutic targets. Despite this potential, the predominating uncertainty about their functional implication in tumor-host interaction hampers their evaluation as a target for cancer therapy. By means of a highly physiologic, spontaneous tumor model in mice, we establish a causal link between B7-H3 and host tumor control and found B7-H4 to be redundant.
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U2 - 10.1158/2326-6066.CIR-15-0100
DO - 10.1158/2326-6066.CIR-15-0100
M3 - Article
C2 - 26122284
AN - SCOPUS:84962022213
SN - 2326-6066
VL - 3
SP - 849
EP - 854
JO - Cancer Immunology Research
JF - Cancer Immunology Research
IS - 8
ER -