Abnormal bone marrow microenvironment: The “harbor” of acute lymphoblastic leukemia cells

Zehui Chen; Yaxin Zheng; Yaling Yang; Junnan Kang; M. James You; Chen Tian

doi:10.1097/BS9.0000000000000071

Abnormal bone marrow microenvironment: The “harbor” of acute lymphoblastic leukemia cells

Zehui Chen, Yaxin Zheng, Yaling Yang, Junnan Kang, M. James You, Chen Tian

Hematopathology

Research output: Contribution to journal › Review article › peer-review

3 Scopus citations

Abstract

Bone marrow (BM) microenvironment regulates and supports the production of blood cells which are necessary to maintain homeostasis. In analogy to normal hematopoiesis, leukemogenesis is originated from leukemic stem cells (LSCs) which gives rise to more differentiated malignant cells. Leukemia cells occupy BM niches and reconstruct them to support leukemogenesis. The abnormal BM niches are the main sanctuary of LSCs where they can evade chemotherapy-induced death and acquire drug resistance. In this review, we focus on the protective effects of BM niche cells on acute lymphoblastic leukemia cells.

Original language	English (US)
Pages (from-to)	29-34
Number of pages	6
Journal	Blood Science
Volume	3
Issue number	2
DOIs	https://doi.org/10.1097/BS9.0000000000000071
State	Published - Apr 1 2021

Keywords

acute lymphoblastic leukemia
bone marrow microenvironment
osteoblastic niche
vascular niche

ASJC Scopus subject areas

Hematology

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title = "Abnormal bone marrow microenvironment: The “harbor” of acute lymphoblastic leukemia cells",

abstract = "Bone marrow (BM) microenvironment regulates and supports the production of blood cells which are necessary to maintain homeostasis. In analogy to normal hematopoiesis, leukemogenesis is originated from leukemic stem cells (LSCs) which gives rise to more differentiated malignant cells. Leukemia cells occupy BM niches and reconstruct them to support leukemogenesis. The abnormal BM niches are the main sanctuary of LSCs where they can evade chemotherapy-induced death and acquire drug resistance. In this review, we focus on the protective effects of BM niche cells on acute lymphoblastic leukemia cells.",

keywords = "acute lymphoblastic leukemia, bone marrow microenvironment, osteoblastic niche, vascular niche",

author = "Zehui Chen and Yaxin Zheng and Yaling Yang and Junnan Kang and You, {M. James} and Chen Tian",

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T1 - Abnormal bone marrow microenvironment

T2 - The “harbor” of acute lymphoblastic leukemia cells

AU - Chen, Zehui

AU - Zheng, Yaxin

AU - Yang, Yaling

AU - Kang, Junnan

AU - You, M. James

AU - Tian, Chen

PY - 2021/4/1

Y1 - 2021/4/1

N2 - Bone marrow (BM) microenvironment regulates and supports the production of blood cells which are necessary to maintain homeostasis. In analogy to normal hematopoiesis, leukemogenesis is originated from leukemic stem cells (LSCs) which gives rise to more differentiated malignant cells. Leukemia cells occupy BM niches and reconstruct them to support leukemogenesis. The abnormal BM niches are the main sanctuary of LSCs where they can evade chemotherapy-induced death and acquire drug resistance. In this review, we focus on the protective effects of BM niche cells on acute lymphoblastic leukemia cells.

AB - Bone marrow (BM) microenvironment regulates and supports the production of blood cells which are necessary to maintain homeostasis. In analogy to normal hematopoiesis, leukemogenesis is originated from leukemic stem cells (LSCs) which gives rise to more differentiated malignant cells. Leukemia cells occupy BM niches and reconstruct them to support leukemogenesis. The abnormal BM niches are the main sanctuary of LSCs where they can evade chemotherapy-induced death and acquire drug resistance. In this review, we focus on the protective effects of BM niche cells on acute lymphoblastic leukemia cells.

KW - acute lymphoblastic leukemia

KW - bone marrow microenvironment

KW - osteoblastic niche

KW - vascular niche

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AN - SCOPUS:85120472168

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JO - Blood Science

JF - Blood Science

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Abnormal bone marrow microenvironment: The “harbor” of acute lymphoblastic leukemia cells

Abstract

Keywords

ASJC Scopus subject areas

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