TY - JOUR
T1 - ABO blood types and cancer risk-A cohort study of 339,432 subjects in Taiwan
AU - Sun, Wenjie
AU - Wen, Chi Pang
AU - Lin, Jie
AU - Wen, Christopher
AU - Pu, Xia
AU - Huang, Maosheng
AU - Tsai, Min Kuang
AU - Tsao, Chwen Keng
AU - Wu, Xifeng
AU - Chow, Wong Ho
N1 - Publisher Copyright:
© 2014 Elsevier Ltd.
PY - 2015/4/1
Y1 - 2015/4/1
N2 - Background: The associations of laboratory-based ABO phenotypes with cancer risks and mortality have not been systematically determined. Methods: The study subjects were 339,432 healthy individuals with laboratory-based blood types from a Taiwan cohort. Results: Compared to blood type O, blood type A was significantly associated with an elevated risk of stomach cancer incidence (Hazard Ratio [HR], 1.38 [95% CI, 1.11-1.72]) and mortality (HR, 1.38 [95% CI, 1.02-1.86]) compared with blood type O, after adjusting for age, sex, education, smoking, alcohol drinking, physical activity, and body mass index. Non-O blood types were associated with an elevated risk of pancreatic cancer, with blood type B reaching statistical significance for incidence (HR, 1.59 [95% CI, 1.02-2.48]) and mortality (HR, 1.63 [95% CI, 1.02-2.60]). In contrast, kidney cancer risk was inversely associated with blood type AB (HR, 0.41 [95% CI, 0.18-0.93]) compared to type O. Conclusion: Cancer risks vary in people with different ABO blood types, with elevated risks of stomach cancer associated with blood type A and pancreatic cancer associated with non-O blood types (A, B, and AB).
AB - Background: The associations of laboratory-based ABO phenotypes with cancer risks and mortality have not been systematically determined. Methods: The study subjects were 339,432 healthy individuals with laboratory-based blood types from a Taiwan cohort. Results: Compared to blood type O, blood type A was significantly associated with an elevated risk of stomach cancer incidence (Hazard Ratio [HR], 1.38 [95% CI, 1.11-1.72]) and mortality (HR, 1.38 [95% CI, 1.02-1.86]) compared with blood type O, after adjusting for age, sex, education, smoking, alcohol drinking, physical activity, and body mass index. Non-O blood types were associated with an elevated risk of pancreatic cancer, with blood type B reaching statistical significance for incidence (HR, 1.59 [95% CI, 1.02-2.48]) and mortality (HR, 1.63 [95% CI, 1.02-2.60]). In contrast, kidney cancer risk was inversely associated with blood type AB (HR, 0.41 [95% CI, 0.18-0.93]) compared to type O. Conclusion: Cancer risks vary in people with different ABO blood types, with elevated risks of stomach cancer associated with blood type A and pancreatic cancer associated with non-O blood types (A, B, and AB).
KW - ABO blood type
KW - Cancer mortality
KW - Cancer risk
KW - Cohort
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U2 - 10.1016/j.canep.2014.12.006
DO - 10.1016/j.canep.2014.12.006
M3 - Article
C2 - 25600007
AN - SCOPUS:84926204395
SN - 1877-7821
VL - 39
SP - 150
EP - 156
JO - Cancer Epidemiology
JF - Cancer Epidemiology
IS - 2
ER -