Absence of canine oral papillomavirus DNA following prophylactic L1 particle-mediated immunotherapeutic delivery vaccination

Richard A. Moore; P. K. Nicholls; E. B. Santos; G. W. Gough; M. A. Stanley

doi:10.1099/0022-1317-83-9-2299

Absence of canine oral papillomavirus DNA following prophylactic L1 particle-mediated immunotherapeutic delivery vaccination

Richard A. Moore, P. K. Nicholls, E. B. Santos, G. W. Gough, M. A. Stanley

Research output: Contribution to journal › Article › peer-review

21 Scopus citations

Abstract

In the canine oral papillomavirus (COPV) model, following wart regression, COPV DNA was detected by PCR at the challenge site. However, following particle-mediated immunotherapeutic delivery (PMID) of COPV L1 and subsequent challenge, no COPV DNA could be detected. These data support PMID of COPV L1 as a protective vaccine and suggest that PMID of L1 may induce virus clearance.

Original language	English (US)
Pages (from-to)	2299-2301
Number of pages	3
Journal	Journal of General Virology
Volume	83
Issue number	9
DOIs	https://doi.org/10.1099/0022-1317-83-9-2299
State	Published - Sep 2002
Externally published	Yes

ASJC Scopus subject areas

Virology

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10.1099/0022-1317-83-9-2299

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abstract = "In the canine oral papillomavirus (COPV) model, following wart regression, COPV DNA was detected by PCR at the challenge site. However, following particle-mediated immunotherapeutic delivery (PMID) of COPV L1 and subsequent challenge, no COPV DNA could be detected. These data support PMID of COPV L1 as a protective vaccine and suggest that PMID of L1 may induce virus clearance.",

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AB - In the canine oral papillomavirus (COPV) model, following wart regression, COPV DNA was detected by PCR at the challenge site. However, following particle-mediated immunotherapeutic delivery (PMID) of COPV L1 and subsequent challenge, no COPV DNA could be detected. These data support PMID of COPV L1 as a protective vaccine and suggest that PMID of L1 may induce virus clearance.

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Absence of canine oral papillomavirus DNA following prophylactic L1 particle-mediated immunotherapeutic delivery vaccination

Abstract

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