TY - JOUR
T1 - Absolute lymphocyte count is a novel prognostic indicator in ALL and AML
T2 - Implications for risk stratification and future studies
AU - De Angulo, Guillermo
AU - Yuen, Carrie
AU - Palla, Shana L.
AU - Anderson, Peter M.
AU - Zweidler-McKay, Patrick A.
N1 - Copyright:
Copyright 2008 Elsevier B.V., All rights reserved.
PY - 2008/1/15
Y1 - 2008/1/15
N2 - BACKGROUND. Leukemia is the leading cause of disease-related death in children, despite significant improvement in survival and modern risk stratification. The prognostic significance of absolute lymphocyte counts (ALC) was evaluated in young patients with acute myeloblastic leukemia (AML) and acute lymphoblastic leukemia (ALL). METHODS. In all, 171 consecutive de novo cases of AML and ALL, age ≤21 years, were analyzed. Age, initial white blood cell count, cytogenetics, and bone marrow response were compared with lymphocyte, neutrophil, and platelet counts at weekly intervals during induction chemotherapy. RESULTS. ALC is a significant independent predictor of relapse and survival. For example, in patients with AML an ALC on Day 28 of induction (ALC-28) <350 cells/μL predicts very poor survival, with a 5-year relapse-free survival (RFS) of only 10% (hazard ratio [HR] 3.7, P = .003). In contrast, an ALC-15 >350 cells/μL carries an excellent prognosis, with a 5-year overall survival (OS) of 85% (HR 0.2, P =.012). Similarly in ALL, an ALC-15 <350 cells/μL predicts poor survival, with a 6-year RFS of 43% (HR 4.5, P = .002), whereas an ALC-15 >350 cells/μL predicts excellent outcome, with a 6-year OS of 87% (HR 0.2, P = .018). Importantly, ALC remains a strong predictor in multivariate analysis with known prognostic factors. CONCLUSIONS. ALC is a simple, statistically powerful measurement for patients with de novo AML and ALL. The results, when combined with previous studies, demonstrate that ALC is a powerful new prognostic factor for a range of malignancies. These findings suggest a need for further exploration of postchemotherapy immune status and immune-modulating cancer therapies.
AB - BACKGROUND. Leukemia is the leading cause of disease-related death in children, despite significant improvement in survival and modern risk stratification. The prognostic significance of absolute lymphocyte counts (ALC) was evaluated in young patients with acute myeloblastic leukemia (AML) and acute lymphoblastic leukemia (ALL). METHODS. In all, 171 consecutive de novo cases of AML and ALL, age ≤21 years, were analyzed. Age, initial white blood cell count, cytogenetics, and bone marrow response were compared with lymphocyte, neutrophil, and platelet counts at weekly intervals during induction chemotherapy. RESULTS. ALC is a significant independent predictor of relapse and survival. For example, in patients with AML an ALC on Day 28 of induction (ALC-28) <350 cells/μL predicts very poor survival, with a 5-year relapse-free survival (RFS) of only 10% (hazard ratio [HR] 3.7, P = .003). In contrast, an ALC-15 >350 cells/μL carries an excellent prognosis, with a 5-year overall survival (OS) of 85% (HR 0.2, P =.012). Similarly in ALL, an ALC-15 <350 cells/μL predicts poor survival, with a 6-year RFS of 43% (HR 4.5, P = .002), whereas an ALC-15 >350 cells/μL predicts excellent outcome, with a 6-year OS of 87% (HR 0.2, P = .018). Importantly, ALC remains a strong predictor in multivariate analysis with known prognostic factors. CONCLUSIONS. ALC is a simple, statistically powerful measurement for patients with de novo AML and ALL. The results, when combined with previous studies, demonstrate that ALC is a powerful new prognostic factor for a range of malignancies. These findings suggest a need for further exploration of postchemotherapy immune status and immune-modulating cancer therapies.
KW - Absolute lymphocyte count
KW - Acute lymphoblastic leukemia
KW - Acute myeloid leukemia
KW - Leukemia
KW - Leukemia survival
KW - Pediatrics
KW - Prognostic factor
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U2 - 10.1002/cncr.23168
DO - 10.1002/cncr.23168
M3 - Article
C2 - 18058809
AN - SCOPUS:38049003498
SN - 0008-543X
VL - 112
SP - 407
EP - 415
JO - Cancer
JF - Cancer
IS - 2
ER -