TY - JOUR
T1 - Accelerating the development of novel molecular imaging probes
T2 - A role for high-throughput screening
AU - Manning, H. Charles
AU - Lander, Adam
AU - McKinley, Eliot
AU - Mutic, Nathan J.
PY - 2008/9/1
Y1 - 2008/9/1
N2 - Molecular imaging is a rapidly emerging research tool and clinical discipline aimed at noninvasive, quantitative visualization of in vivo molecular processes occurring at cellular and subcellular levels. At present, advancement of the molecular imaging field is driven by the development of improved imaging hardware for use in preclinical and clinical settings, the identification and validation of new, biologically relevant imaging targets, and the development of improved imaging probes derived from novel chemistries. Of these 3 essential facets, which comprise a majority of current molecular imaging research, hardware development and novel target discovery significantly outpace the development and clinical advancement of new molecular imaging probes, particularly with respect to cancer imaging.
AB - Molecular imaging is a rapidly emerging research tool and clinical discipline aimed at noninvasive, quantitative visualization of in vivo molecular processes occurring at cellular and subcellular levels. At present, advancement of the molecular imaging field is driven by the development of improved imaging hardware for use in preclinical and clinical settings, the identification and validation of new, biologically relevant imaging targets, and the development of improved imaging probes derived from novel chemistries. Of these 3 essential facets, which comprise a majority of current molecular imaging research, hardware development and novel target discovery significantly outpace the development and clinical advancement of new molecular imaging probes, particularly with respect to cancer imaging.
KW - HTS
KW - Imaging probe discovery
KW - Molecular imaging
UR - http://www.scopus.com/inward/record.url?scp=51349163965&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=51349163965&partnerID=8YFLogxK
U2 - 10.2967/jnumed.108.053009
DO - 10.2967/jnumed.108.053009
M3 - Short survey
C2 - 18703594
AN - SCOPUS:51349163965
SN - 0161-5505
VL - 49
SP - 1401
EP - 1404
JO - Journal of Nuclear Medicine
JF - Journal of Nuclear Medicine
IS - 9
ER -