TY - JOUR
T1 - Accuracy of in vivo multimodal optical imaging for detection of oral neoplasia
AU - Pierce, Mark C.
AU - Schwarz, Richard A.
AU - Bhattar, Vijayashree S.
AU - Mondrik, Sharon
AU - Williams, Michelle D.
AU - Lee, J. Jack
AU - Richards-Kortum, Rebecca
AU - Gillenwater, Ann M.
PY - 2012/6
Y1 - 2012/6
N2 - If detected early, oral cancer is eminently curable. However, survival rates for oral cancer patients remain low, largely due to late-stage diagnosis and subsequent difficulty of treatment. To improve clinicians' ability to detect early disease and to treat advanced cancers, we developed a multimodal optical imaging system (MMIS) to evaluate tissue in situ, at macroscopic and microscopic scales. The MMIS was used to measure 100 anatomic sites in 30 patients, correctly classifying 98% of pathologically confirmed normal tissue sites, and 95% of sites graded as moderate dysplasia, severe dysplasia, or cancer. When used alone, MMIS classification accuracy was 35% for sites determined by pathology as mild dysplasia. However, MMIS measurements correlated with expression of candidate molecular markers in 87% of sites with mild dysplasia. These findings support the ability of noninvasive multimodal optical imaging to accurately identify neoplastic tissue and premalignant lesions. This in turn may have considerable impact on detection and treatment of patients with oral cancer and other epithelial malignancies.
AB - If detected early, oral cancer is eminently curable. However, survival rates for oral cancer patients remain low, largely due to late-stage diagnosis and subsequent difficulty of treatment. To improve clinicians' ability to detect early disease and to treat advanced cancers, we developed a multimodal optical imaging system (MMIS) to evaluate tissue in situ, at macroscopic and microscopic scales. The MMIS was used to measure 100 anatomic sites in 30 patients, correctly classifying 98% of pathologically confirmed normal tissue sites, and 95% of sites graded as moderate dysplasia, severe dysplasia, or cancer. When used alone, MMIS classification accuracy was 35% for sites determined by pathology as mild dysplasia. However, MMIS measurements correlated with expression of candidate molecular markers in 87% of sites with mild dysplasia. These findings support the ability of noninvasive multimodal optical imaging to accurately identify neoplastic tissue and premalignant lesions. This in turn may have considerable impact on detection and treatment of patients with oral cancer and other epithelial malignancies.
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U2 - 10.1158/1940-6207.CAPR-11-0555
DO - 10.1158/1940-6207.CAPR-11-0555
M3 - Article
C2 - 22551901
AN - SCOPUS:84866449932
SN - 1940-6207
VL - 5
SP - 801
EP - 809
JO - Cancer Prevention Research
JF - Cancer Prevention Research
IS - 6
ER -