Achieving cell penetration with distance-matching cysteine cross-linkers: A facile route to cell-permeable peptide dual inhibitors of Mdm2/Mdmx

Avinash Muppidi; Zhiyong Wang; Xiaolong Li; Jiandong Chen; Qing Lin

doi:10.1039/c1cc13320a

Achieving cell penetration with distance-matching cysteine cross-linkers: A facile route to cell-permeable peptide dual inhibitors of Mdm2/Mdmx

Avinash Muppidi, Zhiyong Wang, Xiaolong Li, Jiandong Chen, Qing Lin

Neuro-Oncology

Research output: Contribution to journal › Article › peer-review

74 Scopus citations

Abstract

We report the design of bisarylmethylene bromides as a new class of rigid, distance-matching cysteine cross-linkers. By cross-linking a peptide dual inhibitor of Mdm2/Mdmx containing cysteines at i,i+7 positions, dramatic enhancement in cell permeability was achieved, along with increased helicity and biological activity.

Original language	English (US)
Pages (from-to)	9396-9398
Number of pages	3
Journal	Chemical Communications
Volume	47
Issue number	33
DOIs	https://doi.org/10.1039/c1cc13320a
State	Published - Sep 7 2011

ASJC Scopus subject areas

Catalysis
Electronic, Optical and Magnetic Materials
Ceramics and Composites
General Chemistry
Surfaces, Coatings and Films
Metals and Alloys
Materials Chemistry

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AU - Chen, Jiandong

AU - Lin, Qing

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Achieving cell penetration with distance-matching cysteine cross-linkers: A facile route to cell-permeable peptide dual inhibitors of Mdm2/Mdmx

Abstract

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