Abstract
A listericidal factor was released by monolayers of peritoneal cells from BCG-immune guinea pigs following incubation with PPD in cell culture. Significantly less listericidal factor was released by monolayers of BCG-immune cells incubated without PPD, or by monolayers of nonimmune cells incubated in the presence or absence of antigen. Culture supernatants containing listericidal factor were active at a dilution of 1:10, but supernatants diluted 1:100 were not listericidal. Dialysis of supernatants against fresh tissue culture medium did not affect their ability to kill Listeria, although heating at 60 °C for 30 min destroyed all activity. Supernatants from cultures of guinea pig fibroblasts or ascites-form hepatoma were not listericidal.
Original language | English (US) |
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Pages (from-to) | 248-259 |
Number of pages | 12 |
Journal | Cellular Immunology |
Volume | 10 |
Issue number | 2 |
DOIs | |
State | Published - Feb 1974 |
Externally published | Yes |
ASJC Scopus subject areas
- Immunology