TY - JOUR
T1 - Actinomycin D and radiation
T2 - Effects on mouse lung
AU - Hill, Sally A.
AU - Travis, Elizabeth L.
AU - Denekamp, Juliana
N1 - Copyright:
Copyright 2014 Elsevier B.V., All rights reserved.
PY - 1986/5
Y1 - 1986/5
N2 - The effect of actinomycin D (0.4 mg/kg) on radiation-induced lung damage in the mouse was investigated. The drug was administered either 4 weeks before, immediately after, or 16 weeks after single doses of 240 kV X-rays applied to the thorax of CBA mice. Lung damage was assessed by measuring respiration rate, with a whole body plethysmograph. Dose-response curves were obtained at 2-week intervals from 12 to 40 weeks after irradiation. Actinomycin D had no significant effect on respiration rate in this study. A summary of other experimental studies is included which shows conflicting results.
AB - The effect of actinomycin D (0.4 mg/kg) on radiation-induced lung damage in the mouse was investigated. The drug was administered either 4 weeks before, immediately after, or 16 weeks after single doses of 240 kV X-rays applied to the thorax of CBA mice. Lung damage was assessed by measuring respiration rate, with a whole body plethysmograph. Dose-response curves were obtained at 2-week intervals from 12 to 40 weeks after irradiation. Actinomycin D had no significant effect on respiration rate in this study. A summary of other experimental studies is included which shows conflicting results.
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U2 - 10.1016/0277-5379(86)90046-5
DO - 10.1016/0277-5379(86)90046-5
M3 - Article
C2 - 3770029
AN - SCOPUS:0022634664
SN - 0277-5379
VL - 22
SP - 577
EP - 582
JO - European Journal of Cancer and Clinical Oncology
JF - European Journal of Cancer and Clinical Oncology
IS - 5
ER -