Activation of nuclear factor κB (NF-κB) in prostate cancer is mediated by protein kinase C ∈ (PKC∈)

Rachana Garg; Jorge Blando; Carlos J. Perez; Hong Bin Wang; Fernando J. Benavides; Marcelo G. Kazanietz

doi:10.1074/jbc.M112.398925

Activation of nuclear factor κB (NF-κB) in prostate cancer is mediated by protein kinase C ∈ (PKC∈)

Rachana Garg, Jorge Blando, Carlos J. Perez, Hong Bin Wang, Fernando J. Benavides, Marcelo G. Kazanietz

Research output: Contribution to journal › Article › peer-review

62 Scopus citations

Abstract

Background: PKC∈, a potential oncogene, is up-regulated in prostate cancer. Results: PKC∈ facilitates the formation of TNFR-I complex to regulate the NF-κB pathway via a C1 domain/diacylglycerol-dependent mechanism. Conclusion: PKC∈ is an upstream regulator of NF-κB signaling in prostate cancer. Significance: Mechanisms identified here may reveal novel PKC∈ effectors that contribute to prostate cancer progression and highlight the potential relevance of this pathway for therapeutic purposes.

Original language	English (US)
Pages (from-to)	37570-37582
Number of pages	13
Journal	Journal of Biological Chemistry
Volume	287
Issue number	44
DOIs	https://doi.org/10.1074/jbc.M112.398925
State	Published - Oct 26 2012
Externally published	Yes

ASJC Scopus subject areas

Biochemistry
Molecular Biology
Cell Biology

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10.1074/jbc.M112.398925

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title = "Activation of nuclear factor κB (NF-κB) in prostate cancer is mediated by protein kinase C ∈ (PKC∈)",

abstract = "Background: PKC∈, a potential oncogene, is up-regulated in prostate cancer. Results: PKC∈ facilitates the formation of TNFR-I complex to regulate the NF-κB pathway via a C1 domain/diacylglycerol-dependent mechanism. Conclusion: PKC∈ is an upstream regulator of NF-κB signaling in prostate cancer. Significance: Mechanisms identified here may reveal novel PKC∈ effectors that contribute to prostate cancer progression and highlight the potential relevance of this pathway for therapeutic purposes.",

author = "Rachana Garg and Jorge Blando and Perez, {Carlos J.} and Wang, {Hong Bin} and Benavides, {Fernando J.} and Kazanietz, {Marcelo G.}",

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doi = "10.1074/jbc.M112.398925",

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T1 - Activation of nuclear factor κB (NF-κB) in prostate cancer is mediated by protein kinase C ∈ (PKC∈)

AU - Garg, Rachana

AU - Blando, Jorge

AU - Perez, Carlos J.

AU - Wang, Hong Bin

AU - Benavides, Fernando J.

AU - Kazanietz, Marcelo G.

PY - 2012/10/26

Y1 - 2012/10/26

N2 - Background: PKC∈, a potential oncogene, is up-regulated in prostate cancer. Results: PKC∈ facilitates the formation of TNFR-I complex to regulate the NF-κB pathway via a C1 domain/diacylglycerol-dependent mechanism. Conclusion: PKC∈ is an upstream regulator of NF-κB signaling in prostate cancer. Significance: Mechanisms identified here may reveal novel PKC∈ effectors that contribute to prostate cancer progression and highlight the potential relevance of this pathway for therapeutic purposes.

AB - Background: PKC∈, a potential oncogene, is up-regulated in prostate cancer. Results: PKC∈ facilitates the formation of TNFR-I complex to regulate the NF-κB pathway via a C1 domain/diacylglycerol-dependent mechanism. Conclusion: PKC∈ is an upstream regulator of NF-κB signaling in prostate cancer. Significance: Mechanisms identified here may reveal novel PKC∈ effectors that contribute to prostate cancer progression and highlight the potential relevance of this pathway for therapeutic purposes.

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Activation of nuclear factor κB (NF-κB) in prostate cancer is mediated by protein kinase C ∈ (PKC∈)

Abstract

ASJC Scopus subject areas

MD Anderson CCSG core facilities

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