Acute acalculous cholecystitis in hospitalized patients with hematologic malignancies and prognostic importance of gallbladder ultrasound findings

Rajesh Thampy, Ahmad Khan, Islam H. Zaki, Wei Wei, Brinda Rao Korivi, Greg Staerkel, Tharakeswara K Bathala

Research output: Contribution to journalArticle

Abstract

Objectives-Patients with hematologic malignancies, especially those with acute disease or those receiving intense chemotherapy, are known to develop acute acalculous cholecystitis (AAC). The aim of this study was to evaluate the diagnostic and prognostic value of the established ultrasound (US) diagnostic criteria for AAC in patients with acute hematologic malignancies who were clinically suspected to have AAC. Methods-We retrospectively studied the US findings of the gallbladder in patients with hematologic malignancies and correlated these findings with the duration of clinical symptoms, complications, and gallbladder-specific mortality. The major criteria were a 3.5-mm or thicker wall, pericholecystic fluid, intramural gas, and a sloughed mucosal membrane. The minor criteria were echogenic bile and hydrops (gallbladder distension>4 cm). Ultrasound findings were considered positive if they included 2 major criteria or 1 major and 2 minor criteria. Results-Ninety-four (25.5%) of 368 patients with hematologic malignancies had clinical signs of AAC during their acute phase of illness or during intense chemotherapy. Forty-three (45.7%) of these 94 patients had AAC-positive test results based on US criteria. The mean duration of symptoms was significantly longer (7.8 days) in this group than among the patients with negative test results (3.9 days; P<.001). Patients with positive test results had a higher rate of complications or mortality (20.9%) than those with negative test results (0%; P<.001). Conclusions-Symptomatic patients who meet the US criteria for the diagnosis of AAC have a poor prognosis. Other patients require a close follow-up US examination within 1 week to detect early progression.

LanguageEnglish (US)
Pages51-59
Number of pages9
JournalJournal of Ultrasound in Medicine
Volume38
Issue number1
DOIs
StatePublished - Jan 1 2019

Fingerprint

Acalculous Cholecystitis
Acute Cholecystitis
Hematologic Neoplasms
Gallbladder
Drug Therapy
Mortality
Acute Disease
Bile
Ultrasonography
Edema
Gases

Keywords

  • Acute acalculous cholecystitis
  • Complications
  • Gallbladder
  • Hematologic malignancies
  • Ultrasound

ASJC Scopus subject areas

  • Radiological and Ultrasound Technology
  • Radiology Nuclear Medicine and imaging

Cite this

Acute acalculous cholecystitis in hospitalized patients with hematologic malignancies and prognostic importance of gallbladder ultrasound findings. / Thampy, Rajesh; Khan, Ahmad; Zaki, Islam H.; Wei, Wei; Rao Korivi, Brinda; Staerkel, Greg; Bathala, Tharakeswara K.

In: Journal of Ultrasound in Medicine, Vol. 38, No. 1, 01.01.2019, p. 51-59.

Research output: Contribution to journalArticle

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abstract = "Objectives-Patients with hematologic malignancies, especially those with acute disease or those receiving intense chemotherapy, are known to develop acute acalculous cholecystitis (AAC). The aim of this study was to evaluate the diagnostic and prognostic value of the established ultrasound (US) diagnostic criteria for AAC in patients with acute hematologic malignancies who were clinically suspected to have AAC. Methods-We retrospectively studied the US findings of the gallbladder in patients with hematologic malignancies and correlated these findings with the duration of clinical symptoms, complications, and gallbladder-specific mortality. The major criteria were a 3.5-mm or thicker wall, pericholecystic fluid, intramural gas, and a sloughed mucosal membrane. The minor criteria were echogenic bile and hydrops (gallbladder distension>4 cm). Ultrasound findings were considered positive if they included 2 major criteria or 1 major and 2 minor criteria. Results-Ninety-four (25.5{\%}) of 368 patients with hematologic malignancies had clinical signs of AAC during their acute phase of illness or during intense chemotherapy. Forty-three (45.7{\%}) of these 94 patients had AAC-positive test results based on US criteria. The mean duration of symptoms was significantly longer (7.8 days) in this group than among the patients with negative test results (3.9 days; P<.001). Patients with positive test results had a higher rate of complications or mortality (20.9{\%}) than those with negative test results (0{\%}; P<.001). Conclusions-Symptomatic patients who meet the US criteria for the diagnosis of AAC have a poor prognosis. Other patients require a close follow-up US examination within 1 week to detect early progression.",
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