Acute hypotensive reaction to etoposide with successful rechallenge: Case report and review of the literature

R. J. Cersosimo; P. Calarese; D. D. Karp

doi:10.1177/106002808902301108

Acute hypotensive reaction to etoposide with successful rechallenge: Case report and review of the literature

R. J. Cersosimo, P. Calarese, D. D. Karp

Research output: Contribution to journal › Review article › peer-review

13 Scopus citations

Abstract

Hypotension, bronchospasm, and facial flushing associated with an intravenous infusion of etoposide occurred in a 38-year-old man with advanced testicular cancer. The reaction began within three minutes after the initiation of the infusion and was reversed with intravenous fluids and diphenhydramine. He was successfully retreated with four additional doses of etoposide after pretreatment with diphenhydramine and dexamethasone. The literature concerning similar anaphylactoid reactions to intravenous etoposide is reviewed.

Original language	English (US)
Pages (from-to)	876-877
Number of pages	2
Journal	DICP, Annals of Pharmacotherapy
Volume	23
Issue number	11
DOIs	https://doi.org/10.1177/106002808902301108
State	Published - 1989
Externally published	Yes

ASJC Scopus subject areas

Pharmacology, Toxicology and Pharmaceutics(all)
Pharmacology (medical)

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10.1177/106002808902301108

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abstract = "Hypotension, bronchospasm, and facial flushing associated with an intravenous infusion of etoposide occurred in a 38-year-old man with advanced testicular cancer. The reaction began within three minutes after the initiation of the infusion and was reversed with intravenous fluids and diphenhydramine. He was successfully retreated with four additional doses of etoposide after pretreatment with diphenhydramine and dexamethasone. The literature concerning similar anaphylactoid reactions to intravenous etoposide is reviewed.",

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AU - Calarese, P.

AU - Karp, D. D.

PY - 1989

Y1 - 1989

N2 - Hypotension, bronchospasm, and facial flushing associated with an intravenous infusion of etoposide occurred in a 38-year-old man with advanced testicular cancer. The reaction began within three minutes after the initiation of the infusion and was reversed with intravenous fluids and diphenhydramine. He was successfully retreated with four additional doses of etoposide after pretreatment with diphenhydramine and dexamethasone. The literature concerning similar anaphylactoid reactions to intravenous etoposide is reviewed.

AB - Hypotension, bronchospasm, and facial flushing associated with an intravenous infusion of etoposide occurred in a 38-year-old man with advanced testicular cancer. The reaction began within three minutes after the initiation of the infusion and was reversed with intravenous fluids and diphenhydramine. He was successfully retreated with four additional doses of etoposide after pretreatment with diphenhydramine and dexamethasone. The literature concerning similar anaphylactoid reactions to intravenous etoposide is reviewed.

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ER -

Acute hypotensive reaction to etoposide with successful rechallenge: Case report and review of the literature

Abstract

ASJC Scopus subject areas

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