Acute lymphoblastic leukemia with myeloperoxidase activity

Susan Wright; Antoine Chucrallah; Yap Yee Chong; Hagop Kantarjian; Michael Keating; Maher Albitar

doi:10.1002/(SICI)1096-8652(199602)51:2<147::AID-AJH9>3.0.CO;2-Y

Acute lymphoblastic leukemia with myeloperoxidase activity

Susan Wright, Antoine Chucrallah, Yap Yee Chong, Hagop Kantarjian, Michael Keating, Maher Albitar

Leukemia

Research output: Contribution to journal › Article › peer-review

13 Scopus citations

Abstract

The French-American-British (FAB) classification of acute leukemias is based on the light microscopic detection of myeloperoxidase (MPO) activity in blast cells. Cells with MPO activity in >3% of cells are classified as acute myeloid leukemia (AML) and usually express myeloid cell surface antigens. We describe a case of acute leukemia in which the blast cells have lymphoid morphology, ultrastructure, immunophenotype, and molecular rearrangements, but express significant amounts of MPO. We discuss the incidence, features, and outcome of MPO-positive acute lymphoblastic leukemia (ALL).

Original language	English (US)
Pages (from-to)	147-151
Number of pages	5
Journal	American journal of hematology
Volume	51
Issue number	2
DOIs	https://doi.org/10.1002/(SICI)1096-8652(199602)51:2<147::AID-AJH9>3.0.CO;2-Y
State	Published - Feb 1996

Keywords

Acute lymphoblastic leukemia
Biphenotypic
Electron microscopy
Myeloperoxidase

ASJC Scopus subject areas

Hematology

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10.1002/(SICI)1096-8652(199602)51:2<147::AID-AJH9>3.0.CO;2-Y

Cite this

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title = "Acute lymphoblastic leukemia with myeloperoxidase activity",

abstract = "The French-American-British (FAB) classification of acute leukemias is based on the light microscopic detection of myeloperoxidase (MPO) activity in blast cells. Cells with MPO activity in >3% of cells are classified as acute myeloid leukemia (AML) and usually express myeloid cell surface antigens. We describe a case of acute leukemia in which the blast cells have lymphoid morphology, ultrastructure, immunophenotype, and molecular rearrangements, but express significant amounts of MPO. We discuss the incidence, features, and outcome of MPO-positive acute lymphoblastic leukemia (ALL).",

keywords = "Acute lymphoblastic leukemia, Biphenotypic, Electron microscopy, Myeloperoxidase",

author = "Susan Wright and Antoine Chucrallah and Chong, {Yap Yee} and Hagop Kantarjian and Michael Keating and Maher Albitar",

year = "1996",

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T1 - Acute lymphoblastic leukemia with myeloperoxidase activity

AU - Wright, Susan

AU - Chucrallah, Antoine

AU - Chong, Yap Yee

AU - Kantarjian, Hagop

AU - Keating, Michael

AU - Albitar, Maher

PY - 1996/2

Y1 - 1996/2

N2 - The French-American-British (FAB) classification of acute leukemias is based on the light microscopic detection of myeloperoxidase (MPO) activity in blast cells. Cells with MPO activity in >3% of cells are classified as acute myeloid leukemia (AML) and usually express myeloid cell surface antigens. We describe a case of acute leukemia in which the blast cells have lymphoid morphology, ultrastructure, immunophenotype, and molecular rearrangements, but express significant amounts of MPO. We discuss the incidence, features, and outcome of MPO-positive acute lymphoblastic leukemia (ALL).

AB - The French-American-British (FAB) classification of acute leukemias is based on the light microscopic detection of myeloperoxidase (MPO) activity in blast cells. Cells with MPO activity in >3% of cells are classified as acute myeloid leukemia (AML) and usually express myeloid cell surface antigens. We describe a case of acute leukemia in which the blast cells have lymphoid morphology, ultrastructure, immunophenotype, and molecular rearrangements, but express significant amounts of MPO. We discuss the incidence, features, and outcome of MPO-positive acute lymphoblastic leukemia (ALL).

KW - Acute lymphoblastic leukemia

KW - Biphenotypic

KW - Electron microscopy

KW - Myeloperoxidase

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JO - American journal of hematology

JF - American journal of hematology

IS - 2

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Acute lymphoblastic leukemia with myeloperoxidase activity

Abstract

Keywords

ASJC Scopus subject areas

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