Acute pancreatitis during immunosuppression with tacrolimus following an allogeneic umbilical cord blood transplantation

Y. Nieto; P. Russ; G. Everson; S. I. Bearman; P. J. Cagnoni; R. B. Jones; E. J. Shpall

doi:10.1038/sj.bmt.1702471

Acute pancreatitis during immunosuppression with tacrolimus following an allogeneic umbilical cord blood transplantation

Y. Nieto, P. Russ, G. Everson, S. I. Bearman, P. J. Cagnoni, R. B. Jones, E. J. Shpall

Stem Cell Transplantation

Research output: Contribution to journal › Article › peer-review

35 Scopus citations

Abstract

Tacrolimus is increasingly used for graft-versus-host disease (GVHD) prophylaxis and therapy in the allogeneic stem cell transplant (allo-SCT) setting. Pancreatitis, previously described as a side-effect of cyclosporine, has not been reported in allo-SCT recipients receiving tacrolimus. We present here a case of acute pancreatitis in a 28-year-old patient with chronic myelogenous leukemia (CML) who received an unrelated umbilical cord blood transplant (UCBT) and tacrolimus for GVHD prophylaxis. On day +31 post-transplant, she developed severe acute pancreatitis with multiorgan failure, from which she recovered completely. Tacrolimus was the probable cause of pancreatitis in this patient.

Original language	English (US)
Pages (from-to)	109-111
Number of pages	3
Journal	Bone marrow transplantation
Volume	26
Issue number	1
DOIs	https://doi.org/10.1038/sj.bmt.1702471
State	Published - 2000

Keywords

Cord blood transplant
FK506
Pancreatitis
Tacrolimus

ASJC Scopus subject areas

Hematology
Transplantation

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10.1038/sj.bmt.1702471

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title = "Acute pancreatitis during immunosuppression with tacrolimus following an allogeneic umbilical cord blood transplantation",

abstract = "Tacrolimus is increasingly used for graft-versus-host disease (GVHD) prophylaxis and therapy in the allogeneic stem cell transplant (allo-SCT) setting. Pancreatitis, previously described as a side-effect of cyclosporine, has not been reported in allo-SCT recipients receiving tacrolimus. We present here a case of acute pancreatitis in a 28-year-old patient with chronic myelogenous leukemia (CML) who received an unrelated umbilical cord blood transplant (UCBT) and tacrolimus for GVHD prophylaxis. On day +31 post-transplant, she developed severe acute pancreatitis with multiorgan failure, from which she recovered completely. Tacrolimus was the probable cause of pancreatitis in this patient.",

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T1 - Acute pancreatitis during immunosuppression with tacrolimus following an allogeneic umbilical cord blood transplantation

AU - Nieto, Y.

AU - Russ, P.

AU - Everson, G.

AU - Bearman, S. I.

AU - Cagnoni, P. J.

AU - Jones, R. B.

AU - Shpall, E. J.

PY - 2000

Y1 - 2000

N2 - Tacrolimus is increasingly used for graft-versus-host disease (GVHD) prophylaxis and therapy in the allogeneic stem cell transplant (allo-SCT) setting. Pancreatitis, previously described as a side-effect of cyclosporine, has not been reported in allo-SCT recipients receiving tacrolimus. We present here a case of acute pancreatitis in a 28-year-old patient with chronic myelogenous leukemia (CML) who received an unrelated umbilical cord blood transplant (UCBT) and tacrolimus for GVHD prophylaxis. On day +31 post-transplant, she developed severe acute pancreatitis with multiorgan failure, from which she recovered completely. Tacrolimus was the probable cause of pancreatitis in this patient.

AB - Tacrolimus is increasingly used for graft-versus-host disease (GVHD) prophylaxis and therapy in the allogeneic stem cell transplant (allo-SCT) setting. Pancreatitis, previously described as a side-effect of cyclosporine, has not been reported in allo-SCT recipients receiving tacrolimus. We present here a case of acute pancreatitis in a 28-year-old patient with chronic myelogenous leukemia (CML) who received an unrelated umbilical cord blood transplant (UCBT) and tacrolimus for GVHD prophylaxis. On day +31 post-transplant, she developed severe acute pancreatitis with multiorgan failure, from which she recovered completely. Tacrolimus was the probable cause of pancreatitis in this patient.

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Acute pancreatitis during immunosuppression with tacrolimus following an allogeneic umbilical cord blood transplantation

Abstract

Keywords

ASJC Scopus subject areas

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