TY - JOUR
T1 - Acute promyelocytic leukemia at time of relapse commonly demonstrates cytogenetic evidence of clonal evolution and variability in blast immunophenotypic features
AU - Dimov, Nikolay D.
AU - Medeiros, L. Jeffrey
AU - Ravandi, Farhad
AU - Bueso-Ramos, Carlos E.
PY - 2010/3
Y1 - 2010/3
N2 - Despite the success of the current therapy for patients with acute promyelocytic leukemia (APL), relapse occurs in up to 30% of patients. The characteristics of relapsed APL are not well described. We evaluated a group of APL cases at relapse and compared the clinicopathologic, immunophenotypic, molecular, and cytogenetic findings with those at initial diagnosis. From a group of 207 patients with APL, in 38 patients morphologic evidence of relapse developed. In 30 patients relapse was isolated to bone marrow, and 8 had extramedullary disease. Blasts were morphologically stable in 37 patients. Changes in the immunophenotypic profile were common, the most frequent being gain of CD34, HLA-DR, or CD33 and attenuation or loss of CD13. Cytogenetic changes were common at relapse. The size of the PML-RARα fusion transcript was invariable. We conclude that changes in the immunophenotype and cytogenetic evidence of clonal evolution are common in APL at the time of relapse.
AB - Despite the success of the current therapy for patients with acute promyelocytic leukemia (APL), relapse occurs in up to 30% of patients. The characteristics of relapsed APL are not well described. We evaluated a group of APL cases at relapse and compared the clinicopathologic, immunophenotypic, molecular, and cytogenetic findings with those at initial diagnosis. From a group of 207 patients with APL, in 38 patients morphologic evidence of relapse developed. In 30 patients relapse was isolated to bone marrow, and 8 had extramedullary disease. Blasts were morphologically stable in 37 patients. Changes in the immunophenotypic profile were common, the most frequent being gain of CD34, HLA-DR, or CD33 and attenuation or loss of CD13. Cytogenetic changes were common at relapse. The size of the PML-RARα fusion transcript was invariable. We conclude that changes in the immunophenotype and cytogenetic evidence of clonal evolution are common in APL at the time of relapse.
KW - APL
KW - Acute promyelocytic leukemia
KW - Cytogenetics
KW - Immunophenotype
KW - PML-RARα
KW - Relapse
KW - t(15;17)
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UR - http://www.scopus.com/inward/citedby.url?scp=77949349104&partnerID=8YFLogxK
U2 - 10.1309/AJCPJ7K0AWMBHMAI
DO - 10.1309/AJCPJ7K0AWMBHMAI
M3 - Article
C2 - 20154288
AN - SCOPUS:77949349104
SN - 0002-9173
VL - 133
SP - 484
EP - 490
JO - American journal of clinical pathology
JF - American journal of clinical pathology
IS - 3
ER -