Adaptive radiotherapy for breast cancer

C. De-Colle; A. Kirby; N. Russell; S. F. Shaitelman; A. Currey; E. Donovan; E. Hahn; K. Han; C. N. Anandadas; F. Mahmood; E. L. Lorenzen; D. van den Bongard; M. L. Groot Koerkamp; A. C. Houweling; M. Nachbar; D. Thorwarth; D. Zips

doi:10.1016/j.ctro.2022.100564

Adaptive radiotherapy for breast cancer

C. De-Colle, A. Kirby, N. Russell, S. F. Shaitelman, A. Currey, E. Donovan, E. Hahn, K. Han, C. N. Anandadas, F. Mahmood, E. L. Lorenzen, D. van den Bongard, M. L. Groot Koerkamp, A. C. Houweling, M. Nachbar, D. Thorwarth, D. Zips

Breast Radiation Oncology

Research output: Contribution to journal › Review article › peer-review

4 Scopus citations

Abstract

Research in the field of local and locoregional breast cancer radiotherapy aims to maintain excellent oncological outcomes while reducing treatment-related toxicity. Adaptive radiotherapy (ART) considers variations in target and organs at risk (OARs) anatomy occurring during the treatment course and integrates these in re-optimized treatment plans. Exploiting ART routinely in clinic may result in smaller target volumes and better OAR sparing, which may lead to reduction of acute as well as late toxicities. In this review MR-guided and CT-guided ART for breast cancer patients according to different clinical scenarios (neoadjuvant and adjuvant partial breast irradiation, whole breast, chest wall and regional nodal irradiation) are reviewed and their advantages as well as challenging aspects discussed.

Original language	English (US)
Article number	100564
Journal	Clinical and Translational Radiation Oncology
Volume	39
DOIs	https://doi.org/10.1016/j.ctro.2022.100564
State	Published - Mar 2023

Keywords

Adaptive radiotherapy
Breast cancer
MR-linac
Partial breast irradiation

ASJC Scopus subject areas

Oncology
Radiology Nuclear Medicine and imaging

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10.1016/j.ctro.2022.100564

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De-Colle, C., Kirby, A., Russell, N., Shaitelman, S. F., Currey, A., Donovan, E., Hahn, E., Han, K., Anandadas, C. N., Mahmood, F., Lorenzen, E. L., van den Bongard, D., Groot Koerkamp, M. L., Houweling, A. C., Nachbar, M., Thorwarth, D., & Zips, D. (2023). Adaptive radiotherapy for breast cancer. Clinical and Translational Radiation Oncology, 39, Article 100564. https://doi.org/10.1016/j.ctro.2022.100564

De-Colle, C, Kirby, A, Russell, N, Shaitelman, SF, Currey, A, Donovan, E, Hahn, E, Han, K, Anandadas, CN, Mahmood, F, Lorenzen, EL, van den Bongard, D, Groot Koerkamp, ML, Houweling, AC, Nachbar, M, Thorwarth, D & Zips, D 2023, 'Adaptive radiotherapy for breast cancer', Clinical and Translational Radiation Oncology, vol. 39, 100564. https://doi.org/10.1016/j.ctro.2022.100564

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abstract = "Research in the field of local and locoregional breast cancer radiotherapy aims to maintain excellent oncological outcomes while reducing treatment-related toxicity. Adaptive radiotherapy (ART) considers variations in target and organs at risk (OARs) anatomy occurring during the treatment course and integrates these in re-optimized treatment plans. Exploiting ART routinely in clinic may result in smaller target volumes and better OAR sparing, which may lead to reduction of acute as well as late toxicities. In this review MR-guided and CT-guided ART for breast cancer patients according to different clinical scenarios (neoadjuvant and adjuvant partial breast irradiation, whole breast, chest wall and regional nodal irradiation) are reviewed and their advantages as well as challenging aspects discussed.",

keywords = "Adaptive radiotherapy, Breast cancer, MR-linac, Partial breast irradiation",

author = "C. De-Colle and A. Kirby and N. Russell and Shaitelman, {S. F.} and A. Currey and E. Donovan and E. Hahn and K. Han and Anandadas, {C. N.} and F. Mahmood and Lorenzen, {E. L.} and {van den Bongard}, D. and {Groot Koerkamp}, {M. L.} and Houweling, {A. C.} and M. Nachbar and D. Thorwarth and D. Zips",

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year = "2023",

month = mar,

doi = "10.1016/j.ctro.2022.100564",

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AU - De-Colle, C.

AU - Kirby, A.

AU - Russell, N.

AU - Shaitelman, S. F.

AU - Currey, A.

AU - Donovan, E.

AU - Hahn, E.

AU - Han, K.

AU - Anandadas, C. N.

AU - Mahmood, F.

AU - Lorenzen, E. L.

AU - van den Bongard, D.

AU - Groot Koerkamp, M. L.

AU - Houweling, A. C.

AU - Nachbar, M.

AU - Thorwarth, D.

AU - Zips, D.

PY - 2023/3

Y1 - 2023/3

N2 - Research in the field of local and locoregional breast cancer radiotherapy aims to maintain excellent oncological outcomes while reducing treatment-related toxicity. Adaptive radiotherapy (ART) considers variations in target and organs at risk (OARs) anatomy occurring during the treatment course and integrates these in re-optimized treatment plans. Exploiting ART routinely in clinic may result in smaller target volumes and better OAR sparing, which may lead to reduction of acute as well as late toxicities. In this review MR-guided and CT-guided ART for breast cancer patients according to different clinical scenarios (neoadjuvant and adjuvant partial breast irradiation, whole breast, chest wall and regional nodal irradiation) are reviewed and their advantages as well as challenging aspects discussed.

AB - Research in the field of local and locoregional breast cancer radiotherapy aims to maintain excellent oncological outcomes while reducing treatment-related toxicity. Adaptive radiotherapy (ART) considers variations in target and organs at risk (OARs) anatomy occurring during the treatment course and integrates these in re-optimized treatment plans. Exploiting ART routinely in clinic may result in smaller target volumes and better OAR sparing, which may lead to reduction of acute as well as late toxicities. In this review MR-guided and CT-guided ART for breast cancer patients according to different clinical scenarios (neoadjuvant and adjuvant partial breast irradiation, whole breast, chest wall and regional nodal irradiation) are reviewed and their advantages as well as challenging aspects discussed.

KW - Adaptive radiotherapy

KW - Breast cancer

KW - MR-linac

KW - Partial breast irradiation

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JO - Clinical and Translational Radiation Oncology

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Adaptive radiotherapy for breast cancer

Abstract

Keywords

ASJC Scopus subject areas

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