Abstract
Background: One of the proposed mechanisms of trastuzumab-induced regression of human epidermal growth factor receptor 2-positive (HER2+) tumours includes facilitation of antibody-dependent cell-mediated cytotoxicity (ADCC). Granulocyte-macrophage colony-stimulating factor (GM-CSF) mediates ADCC. We presented our pilot study of adding GM-CSF to trastuzumab in patients with trastuzumab-resistant HER2+ metastatic breast cancer. Methods: Patients with HER2+ metastatic breast cancer that progressed after trastuzumab / chemotherapy were continued on trastuzumab 2 mg kg-1 intravenous weekly and GM-CSF 250 μgm-2 subcutaneous daily. Patients were assessed for response every 8 weeks. Treatment was continued until disease progression or intolerable toxicity. Results: Seventeen patients were evaluable (median age 48 years, range 27-75 years). The median number of metastatic sites was 2 (range 1-3); the most common site was the liver (n=10). The median number of prior regimens for metastatic disease was 2 (range 1-5). No objective disease response was observed, but five patients (29%) had stable disease for a median duration of 15.8 (range 10-53.9) weeks. The most common adverse event was rash at the injection site. No grade 4 or irreversible adverse event was seen. Conclusion: The addition of GM-CSF to trastuzumab alone had a modest clinical benefit and acceptable safety profile in heavily pretreated patients with trastuzumab-resistant HER2+ metastatic breast cancer.
Original language | English (US) |
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Pages (from-to) | 1331-1334 |
Number of pages | 4 |
Journal | British journal of cancer |
Volume | 103 |
Issue number | 9 |
DOIs | |
State | Published - Oct 26 2010 |
Keywords
- HER2
- granulocyte-macrophage colony-stimulating factor
- metastatic breast cancer
- trastuzumab
ASJC Scopus subject areas
- Oncology
- Cancer Research