TY - JOUR
T1 - Addressing the role of obesity in endometrial cancer risk, prevention, and treatment
AU - Onstad, Michaela A.
AU - Schmandt, Rosemarie
AU - Lu, Karen H.
N1 - Publisher Copyright:
© 2016 by American Society of Clinical Oncology.
PY - 2016/12/10
Y1 - 2016/12/10
N2 - In sharp contrast to many other cancer types, the incidence and mortality of endometrial cancer continue to grow. This unfortunate trend is, in no small part, a result of the worldwide obesity epidemic. More than half of endometrial cancers are currently attributable to obesity, which is recognized as an independent risk factor for this disease. In this review, we identify the molecular mechanisms by which obesity and adipose tissue contribute to the pathogenesis of endometrial cancer. We further discuss the impact of obesity on the clinical management of the disease and examine the development of rational behavioral and pharmaceutical interventions aimed at reducing endometrial cancer risk, improving cancer outcomes, and preserving fertility in an increasingly younger population of patients with endometrial cancer.
AB - In sharp contrast to many other cancer types, the incidence and mortality of endometrial cancer continue to grow. This unfortunate trend is, in no small part, a result of the worldwide obesity epidemic. More than half of endometrial cancers are currently attributable to obesity, which is recognized as an independent risk factor for this disease. In this review, we identify the molecular mechanisms by which obesity and adipose tissue contribute to the pathogenesis of endometrial cancer. We further discuss the impact of obesity on the clinical management of the disease and examine the development of rational behavioral and pharmaceutical interventions aimed at reducing endometrial cancer risk, improving cancer outcomes, and preserving fertility in an increasingly younger population of patients with endometrial cancer.
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U2 - 10.1200/JCO.2016.69.4638
DO - 10.1200/JCO.2016.69.4638
M3 - Review article
C2 - 27903150
AN - SCOPUS:85002989283
SN - 0732-183X
VL - 34
SP - 4225
EP - 4230
JO - Journal of Clinical Oncology
JF - Journal of Clinical Oncology
IS - 35
ER -