TY - JOUR
T1 - Adenocarcinoma of the lower esophagus
T2 - A disease primarily of white men with barrett's esophagus
AU - Rogers, Elizabeth L.
AU - Goldkind, Sara Fay
AU - Iseri, Oscar A.
AU - Bustin, Michael
AU - Goldkind, Lawrence
AU - Hamilton, Stanley R.
AU - Smith, Robert R.L.
PY - 1986/12
Y1 - 1986/12
N2 - Sex and racial predilection, social history, and histology were analyzed in a biopsy-proven adenocarcinoma of the lower esophagus/esophagogastric junction collected over a 5-year period in two teaching institutions with different patient populations. Adenocarcinoma occurred in 11% of patients with biopsy-proven esophageal cancer. The disease occurred only in males at one center, and in a 7:1 ratio of males to females at the other center. Clear racial predilection was seen, since 12 of 13 patients with adenocarcinoma of the esophagus were white, whereas less than 20% of patients with squamous carcinoma of the esophagus were white. The finding of Barrett's epithelium in eight of the 13 cases strongly supports the theory that in white males, Barrett's epithelium is a precursor lesion of adenocarcinoma of the esophagus/esophagogastric junction.
AB - Sex and racial predilection, social history, and histology were analyzed in a biopsy-proven adenocarcinoma of the lower esophagus/esophagogastric junction collected over a 5-year period in two teaching institutions with different patient populations. Adenocarcinoma occurred in 11% of patients with biopsy-proven esophageal cancer. The disease occurred only in males at one center, and in a 7:1 ratio of males to females at the other center. Clear racial predilection was seen, since 12 of 13 patients with adenocarcinoma of the esophagus were white, whereas less than 20% of patients with squamous carcinoma of the esophagus were white. The finding of Barrett's epithelium in eight of the 13 cases strongly supports the theory that in white males, Barrett's epithelium is a precursor lesion of adenocarcinoma of the esophagus/esophagogastric junction.
KW - Adenocarcinoma
KW - Barrett's epithelium
KW - Disease, caucasian males
KW - Esophageal cancer
KW - Esophagus
UR - http://www.scopus.com/inward/record.url?scp=0022975897&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0022975897&partnerID=8YFLogxK
U2 - 10.1097/00004836-198612000-00004
DO - 10.1097/00004836-198612000-00004
M3 - Article
C2 - 3805655
AN - SCOPUS:0022975897
SN - 0192-0790
VL - 8
SP - 613
EP - 618
JO - Journal of Clinical Gastroenterology
JF - Journal of Clinical Gastroenterology
IS - 6
ER -