TY - JOUR
T1 - Adenoid cystic carcinoma of the head and neck
T2 - Predictors of morbidity and mortality
AU - Fordice, Jim
AU - Kershaw, Corey
AU - El-Naggar, Adel
AU - Goepfert, Helmuth
PY - 1999/2
Y1 - 1999/2
N2 - Objectives: To review 160 patients treated at a single institution for adenoid cystic carcinoma during the 20 years between 1977 and 1996, applying a consistent treatment of surgery and postoperative radiation therapy to 140 patients. To analyze factors governing treatment failure, treatment-related morbidity, and mortality. Design: Retrospective review. Setting: Tertiary referral center. Patients: Seventy-seven males and 83 females aged 13 to 89 years (average age, 49.5 years). Results and Conclusions: Combined treatment yielded an 85% locoregional freedom from relapse and disease-specific survival at 5, 10, and 15 years was 89%, 67.4%, and 39.6%, respectively. Thirty-five patients (21.9%) had distant metastases as the only site of failure. Patients treated for paranasal sinus tumor experienced the most treatment-related morbidity vs other sites. Perineural invasion of major nerves, positive margins at surgery, and solid histological features were associated with increased treatment failures. Four or more symptoms present at diagnosis, positive lymph nodes, solid histology, and perineural invasion of major nerves were associated with increased mortality from disease.
AB - Objectives: To review 160 patients treated at a single institution for adenoid cystic carcinoma during the 20 years between 1977 and 1996, applying a consistent treatment of surgery and postoperative radiation therapy to 140 patients. To analyze factors governing treatment failure, treatment-related morbidity, and mortality. Design: Retrospective review. Setting: Tertiary referral center. Patients: Seventy-seven males and 83 females aged 13 to 89 years (average age, 49.5 years). Results and Conclusions: Combined treatment yielded an 85% locoregional freedom from relapse and disease-specific survival at 5, 10, and 15 years was 89%, 67.4%, and 39.6%, respectively. Thirty-five patients (21.9%) had distant metastases as the only site of failure. Patients treated for paranasal sinus tumor experienced the most treatment-related morbidity vs other sites. Perineural invasion of major nerves, positive margins at surgery, and solid histological features were associated with increased treatment failures. Four or more symptoms present at diagnosis, positive lymph nodes, solid histology, and perineural invasion of major nerves were associated with increased mortality from disease.
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U2 - 10.1001/archotol.125.2.149
DO - 10.1001/archotol.125.2.149
M3 - Article
C2 - 10037280
AN - SCOPUS:0032972199
SN - 0886-4470
VL - 125
SP - 149
EP - 152
JO - Archives of Otolaryngology - Head and Neck Surgery
JF - Archives of Otolaryngology - Head and Neck Surgery
IS - 2
ER -