Adenovirus-mediated gene expression in vivo is enhanced by the antiapoptotic Bcl-2 gene

Guadalupe Bilbao; Juan L. Contreras; Huang Ge Zhang; M. Joyce Pike; Ken Overturf; Galina Mikheeva; Victor Krasnykh; David T. Curiel

doi:10.1128/jvi.73.8.6992-7000.1999

Adenovirus-mediated gene expression in vivo is enhanced by the antiapoptotic Bcl-2 gene

Guadalupe Bilbao, Juan L. Contreras, Huang Ge Zhang, M. Joyce Pike, Ken Overturf, Galina Mikheeva, Victor Krasnykh, David T. Curiel

Cancer Systems Imaging

Research output: Contribution to journal › Article › peer-review

18 Scopus citations

Abstract

An adenovirus vector encoding the human Bcl-2 gene (hBcl-2) was derived. In vivo expression of hBcl-2 in murine livers enhanced and prolonged adenovirus-mediated gene expression. Furthermore, in the hBcl-2-treated group a significant reduction in the apoptosis induced by the adenovirus vector was observed. Thus, the cytoprotection of the vector-infected cells with antiapoptotic genes appears promising for successful in vivo gene therapy.

Original language	English (US)
Pages (from-to)	6992-7000
Number of pages	9
Journal	Journal of Virology
Volume	73
Issue number	8
DOIs	https://doi.org/10.1128/jvi.73.8.6992-7000.1999
State	Published - 1999

ASJC Scopus subject areas

Microbiology
Immunology
Insect Science
Virology

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10.1128/jvi.73.8.6992-7000.1999

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title = "Adenovirus-mediated gene expression in vivo is enhanced by the antiapoptotic Bcl-2 gene",

abstract = "An adenovirus vector encoding the human Bcl-2 gene (hBcl-2) was derived. In vivo expression of hBcl-2 in murine livers enhanced and prolonged adenovirus-mediated gene expression. Furthermore, in the hBcl-2-treated group a significant reduction in the apoptosis induced by the adenovirus vector was observed. Thus, the cytoprotection of the vector-infected cells with antiapoptotic genes appears promising for successful in vivo gene therapy.",

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T1 - Adenovirus-mediated gene expression in vivo is enhanced by the antiapoptotic Bcl-2 gene

AU - Bilbao, Guadalupe

AU - Contreras, Juan L.

AU - Zhang, Huang Ge

AU - Pike, M. Joyce

AU - Overturf, Ken

AU - Mikheeva, Galina

AU - Krasnykh, Victor

AU - Curiel, David T.

PY - 1999

Y1 - 1999

N2 - An adenovirus vector encoding the human Bcl-2 gene (hBcl-2) was derived. In vivo expression of hBcl-2 in murine livers enhanced and prolonged adenovirus-mediated gene expression. Furthermore, in the hBcl-2-treated group a significant reduction in the apoptosis induced by the adenovirus vector was observed. Thus, the cytoprotection of the vector-infected cells with antiapoptotic genes appears promising for successful in vivo gene therapy.

AB - An adenovirus vector encoding the human Bcl-2 gene (hBcl-2) was derived. In vivo expression of hBcl-2 in murine livers enhanced and prolonged adenovirus-mediated gene expression. Furthermore, in the hBcl-2-treated group a significant reduction in the apoptosis induced by the adenovirus vector was observed. Thus, the cytoprotection of the vector-infected cells with antiapoptotic genes appears promising for successful in vivo gene therapy.

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U2 - 10.1128/jvi.73.8.6992-7000.1999

DO - 10.1128/jvi.73.8.6992-7000.1999

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AN - SCOPUS:0032809227

SN - 0022-538X

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SP - 6992

EP - 7000

JO - Journal of Virology

JF - Journal of Virology

IS - 8

ER -

Adenovirus-mediated gene expression in vivo is enhanced by the antiapoptotic Bcl-2 gene

Abstract

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