TY - JOUR
T1 - Adequate endocrine and cardiovascular response to social stress in survivors of childhood acute lymphoblastic leukemia
AU - Gordijn, Maartje S.
AU - Gemke, Reinoud J.B.J.
AU - Bierings, Marc B.
AU - Hoogerbrugge, Peter M.
AU - Tersteeg-Kamperman, Marijke D.J.
AU - Heijnen, Cobi J.
AU - Rotteveel, Joost
AU - Kaspers, Gertjan J.L.
N1 - Funding Information:
This study was financially supported by the Dutch Cancer Society .
PY - 2013/12
Y1 - 2013/12
N2 - Survivors of childhood ALL have been demonstrated to have increased morning cortisol levels compared to healthy controls. Information regarding the response of the HPA axis and the sympathetic nervous system to stress in childhood ALL survivors is not available. The present study aimed at assessing the endocrine and cardiovascular stress response in childhood ALL survivors and healthy controls by evaluating perceived stress on visual analog scales, by determining saliva cortisol, blood pressure and heart rate in response to the Trier Social Stress Test for Children (TSST-C). Fifty survivors who had completed their treatment for childhood ALL 57 (IQR 47.0-72.3) months before and 50 healthy age and sex matched controls were included. Exposure to the TSST-C induced a significant response of perceived stress, saliva cortisol and cardiovascular outcome variables in the total study group. These responses did not significantly differ between survivors of childhood ALL and healthy controls. We conclude that the endocrine and cardiovascular response to social stress are intact in survivors of childhood ALL.
AB - Survivors of childhood ALL have been demonstrated to have increased morning cortisol levels compared to healthy controls. Information regarding the response of the HPA axis and the sympathetic nervous system to stress in childhood ALL survivors is not available. The present study aimed at assessing the endocrine and cardiovascular stress response in childhood ALL survivors and healthy controls by evaluating perceived stress on visual analog scales, by determining saliva cortisol, blood pressure and heart rate in response to the Trier Social Stress Test for Children (TSST-C). Fifty survivors who had completed their treatment for childhood ALL 57 (IQR 47.0-72.3) months before and 50 healthy age and sex matched controls were included. Exposure to the TSST-C induced a significant response of perceived stress, saliva cortisol and cardiovascular outcome variables in the total study group. These responses did not significantly differ between survivors of childhood ALL and healthy controls. We conclude that the endocrine and cardiovascular response to social stress are intact in survivors of childhood ALL.
KW - Acute lymphoblastic leukemia
KW - Cardiovascular stress response
KW - Child
KW - HPA axis
KW - Trier Social Stress Test
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U2 - 10.1016/j.psyneuen.2013.07.013
DO - 10.1016/j.psyneuen.2013.07.013
M3 - Article
C2 - 23972944
AN - SCOPUS:84888290427
SN - 0306-4530
VL - 38
SP - 3145
EP - 3149
JO - Psychoneuroendocrinology
JF - Psychoneuroendocrinology
IS - 12
ER -