TY - JOUR
T1 - Adipose stem cell therapy in cancer reconstruction
T2 - A critical review
AU - Alperovich, Michael
AU - Lee, Z. Hye
AU - Friedlander, Paul L.
AU - Rowan, Brian G.
AU - Gimble, Jeffrey M.
AU - Chiu, Ernest S.
PY - 2014/9
Y1 - 2014/9
N2 - Found in most mesenchymally derived organs, mesenchymal stem cells are undifferentiated cells capable of developing into many cell types. Adipose stem cells are a type of mesenchymal stem cell easily extracted from lipoaspirate, often readily available, and are conformable to the tissue defect. Their ability for self-renewal, unlimited proliferation and proangiogenic, and immunomodulatory properties have made them attractive adjuncts in plastic surgery. Since the discovery of pluripotent cells in adipose tissue, plastic surgeons have applied the technology toward improving wound healing, soft tissue augmentation, and tissue engineering. More recently, some surgeons have used adipose stem cells in cancer reconstruction. By mixing lipoaspirate with concentrated fractions of adipose stem cells through a technique termed cell-assisted lipotransfer, plastic surgeons have claimed improved aesthetic results. Promising early results have been tempered by in vitro and animal studies demonstrating increased tumor proliferation and metastasis rates with the use of adipose and other mesenchymal stem cells. This review provides a succinct yet comprehensive overview of the current literature evaluating the oncologic risks associated with adipose stem cell use in cancer.
AB - Found in most mesenchymally derived organs, mesenchymal stem cells are undifferentiated cells capable of developing into many cell types. Adipose stem cells are a type of mesenchymal stem cell easily extracted from lipoaspirate, often readily available, and are conformable to the tissue defect. Their ability for self-renewal, unlimited proliferation and proangiogenic, and immunomodulatory properties have made them attractive adjuncts in plastic surgery. Since the discovery of pluripotent cells in adipose tissue, plastic surgeons have applied the technology toward improving wound healing, soft tissue augmentation, and tissue engineering. More recently, some surgeons have used adipose stem cells in cancer reconstruction. By mixing lipoaspirate with concentrated fractions of adipose stem cells through a technique termed cell-assisted lipotransfer, plastic surgeons have claimed improved aesthetic results. Promising early results have been tempered by in vitro and animal studies demonstrating increased tumor proliferation and metastasis rates with the use of adipose and other mesenchymal stem cells. This review provides a succinct yet comprehensive overview of the current literature evaluating the oncologic risks associated with adipose stem cell use in cancer.
KW - adipose stem cells
KW - cancer reconstruction
KW - oncologic safety
UR - http://www.scopus.com/inward/record.url?scp=84906058542&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84906058542&partnerID=8YFLogxK
U2 - 10.1097/SAP.0000000000000283
DO - 10.1097/SAP.0000000000000283
M3 - Article
C2 - 25003407
AN - SCOPUS:84906058542
SN - 0148-7043
VL - 73
SP - S104-S107
JO - Annals of plastic surgery
JF - Annals of plastic surgery
IS - SUPPL.1
ER -