@article{fe4440b0a96f44a9bb94adc2ce211967,
title = "Adjuvant and salvage therapy with leflunomide for recalcitrant cytomegalovirus infections in hematopoietic cell transplantation recipients: A case series",
abstract = "Cytomegalovirus (CMV) reactivation is a clinically significant complication in hematopoietic stem cell transplant (HCT) recipients. Alternative therapy for multidrug-resistant CMV is limited and often fails. Leflunomide has been used to treat resistant CMV infections, however, data on efficacy, safety, and guidance for therapeutic drug level monitoring are lacking. In this report, we describe 3 HCT recipients with multi-drug resistant CMV infections who received leflunomide as adjuvant and salvage therapy. The therapeutic effect of leflunomide as an anti-CMV agent based on virologic responses and therapeutic drug monitoring were evaluated.",
keywords = "Cytomegalovirus, Drug level, Leflunomide, Resistance, Stem cell transplant",
author = "{El Chaer}, Firas and Nobuyoshi Mori and Dimpy Shah and Nora Oliver and Emily Wang and Anna Jan and Vi Doan and Frank Tverdek and Jean Tayar and Ella Ariza-Heredia and Chemaly, {Roy F.}",
note = "Funding Information: R.F.C. has received research funding from Merck, Chimerix, and Oxford Immunotec and is also a consultant for Merck, Chimerix, and Oxford Immunotec. E.A.H received research funding from Oxford Immunotec. All other authors of this manuscript have no conflicts of interest to disclose. Funding Information: We would like to thank Joe Munch of MD Anderson's Department of Scientific Publications for editing this manuscript. This work was supported in part by the National Cancer Institute at the National Institutes of Health under award number P30CA016672; and used the Cancer Center Support Grant resources. Publisher Copyright: {\textcopyright} 2016 Elsevier B.V.",
year = "2016",
month = nov,
day = "1",
doi = "10.1016/j.antiviral.2016.08.027",
language = "English (US)",
volume = "135",
pages = "91--96",
journal = "Antiviral Research",
issn = "0166-3542",
publisher = "Elsevier",
}