Abstract
Stage III melanoma, defined as regionally advanced disease based on the presence of either microscopic or gross lymph node involvement, remains a challenge for clinicians to treat secondary to the limited therapies that have clearly shown any benefit in overall survival compared with observation alone. The US FDA approved peginterferon alfa-2b (pegIFN alfa-2b) in March 2010 for use in the adjuvant setting to treat stage III malignant melanoma. The approval of pegIFN alfa-2b was based on results from the EORTC 18991 trial, which showed pegIFN alfa-2b had superior relapse-free survival compared with observation alone. PegIFN alfa-2b is administered subcutaneously and, aside from the nonpegylated IFN-α, is the only systemic therapy approved by the FDA to treat stage III melanoma. In this review, emphasis will be placed on describing the history of the use of IFN-α in regionally advanced melanoma, with a primary focus on the efficacy and safety profile of pegIFN alfa-2b as an adjuvant therapy in treating malignant melanoma.
Original language | English (US) |
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Pages (from-to) | 567-575 |
Number of pages | 9 |
Journal | Expert Review of Dermatology |
Volume | 6 |
Issue number | 6 |
DOIs | |
State | Published - Dec 2011 |
Externally published | Yes |
Keywords
- Adjuvant
- IFN-α
- Melanoma
- Peginterferon
- Peginterferon alfa-2b
ASJC Scopus subject areas
- Dermatology