TY - JOUR
T1 - Adolescent and young adult Hodgkin lymphoma patients at risk for subcutaneous fat gain during early cancer treatment
T2 - a brief report
AU - Wooten, Savannah Victoria
AU - Amini, Behrang
AU - Roth, Michael
AU - Leung, Cheuk Hong
AU - Wang, Jian
AU - Hildebrandt, Michelle Ann Theobald
AU - Kleinerman, Eugenie
N1 - Publisher Copyright:
© 2023 Informa UK Limited, trading as Taylor & Francis Group.
PY - 2024
Y1 - 2024
N2 - Computed tomography scans were assessed for subcutaneous fat area and density at thoracic vertebra 4 in 65 adolescent and young adult (AYA) patients with Hodgkin lymphoma. Subcutaneous fat was quantified over 3 timepoints; (1) baseline, (2) end of initial anthracycline treatment (EOT) and (3) 1 year. Fat area increased at EOT (62.3 ± 5.4 cm/m2 vs 53.5 ± 5.0 cm/m2, p < 0.01) and 1 year (65.8 ± 5.6 cm/m2 vs 53.5 ± 5.0 cm/m2, p < 0.01) compared to baseline. Fat density significantly decreased at EOT (-91.2 ± 1.4 HU vs −86.5 ± 1.4 HU, p < 0.01) and at 1 year (-90.3 ± 1.6 HU vs −86.5 ± 1.4 HU, p = 0.01) compared to baseline. Female, radiation receiving, and anthracycline dosage >250mg/m2subgroups experienced significant fat gain (p < 0.05 for all). Female AYA Hodgkin lymphoma patients receiving radiation, and/or high-dose anthracyclines may be at higher risk of subcutaneous fat gain during therapy.
AB - Computed tomography scans were assessed for subcutaneous fat area and density at thoracic vertebra 4 in 65 adolescent and young adult (AYA) patients with Hodgkin lymphoma. Subcutaneous fat was quantified over 3 timepoints; (1) baseline, (2) end of initial anthracycline treatment (EOT) and (3) 1 year. Fat area increased at EOT (62.3 ± 5.4 cm/m2 vs 53.5 ± 5.0 cm/m2, p < 0.01) and 1 year (65.8 ± 5.6 cm/m2 vs 53.5 ± 5.0 cm/m2, p < 0.01) compared to baseline. Fat density significantly decreased at EOT (-91.2 ± 1.4 HU vs −86.5 ± 1.4 HU, p < 0.01) and at 1 year (-90.3 ± 1.6 HU vs −86.5 ± 1.4 HU, p = 0.01) compared to baseline. Female, radiation receiving, and anthracycline dosage >250mg/m2subgroups experienced significant fat gain (p < 0.05 for all). Female AYA Hodgkin lymphoma patients receiving radiation, and/or high-dose anthracyclines may be at higher risk of subcutaneous fat gain during therapy.
KW - Adolescent and young adult cancer
KW - Hodgkin lymphoma
KW - subcutaneous fat
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U2 - 10.1080/10428194.2023.2273747
DO - 10.1080/10428194.2023.2273747
M3 - Article
C2 - 37878765
AN - SCOPUS:85174814438
SN - 1042-8194
VL - 65
SP - 62
EP - 68
JO - Leukemia and Lymphoma
JF - Leukemia and Lymphoma
IS - 1
ER -