TY - JOUR
T1 - Adoptive T cell therapy
T2 - Addressing challenges in cancer immunotherapy
AU - Yee, Cassian
PY - 2005/4/28
Y1 - 2005/4/28
N2 - Adoptive T cell therapy involves the ex vivo selection and expansion of effector cells for the treatment of patients with cancer. In this review, the advantages and limitations of using antigen-specific T cells are discussed in counterpoint to vaccine strategies. Although vaccination strategies represent more readily available reagents, adoptive T cell therapy provides highly selected T cells of defined phenotype, specificity and function that may influence their biological behavior in vivo. Adoptive T cell therapy offers not only translational opportunities but also a means to address fundamental issues in the evolving field of cancer immunotherapy.
AB - Adoptive T cell therapy involves the ex vivo selection and expansion of effector cells for the treatment of patients with cancer. In this review, the advantages and limitations of using antigen-specific T cells are discussed in counterpoint to vaccine strategies. Although vaccination strategies represent more readily available reagents, adoptive T cell therapy provides highly selected T cells of defined phenotype, specificity and function that may influence their biological behavior in vivo. Adoptive T cell therapy offers not only translational opportunities but also a means to address fundamental issues in the evolving field of cancer immunotherapy.
UR - http://www.scopus.com/inward/record.url?scp=20544457460&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=20544457460&partnerID=8YFLogxK
U2 - 10.1186/1479-5876-3-17
DO - 10.1186/1479-5876-3-17
M3 - Review article
C2 - 15860133
AN - SCOPUS:20544457460
SN - 1479-5876
VL - 3
JO - Journal of translational medicine
JF - Journal of translational medicine
M1 - 17
ER -