TY - JOUR
T1 - Adoptive T-Cell Therapy of Cancer
AU - Yee, Cassian
N1 - Funding Information:
Dr. Yee is a Damon Runyon Clinical Investigator supported in part by the Damon Runyon Cancer Research Foundation. This work was also supported by a grant from the National Institutes of Health (R01 CA104711) and the General Clinical Research Center (M01 RR00037).
PY - 2006/6
Y1 - 2006/6
N2 - Adoptive therapy involves the transfer of ex vivo expanded immune effector cells to patients as a means of augmenting the antitumor immune response. In general, this transfer is accomplished by harvesting cells from the peripheral blood, tumor sites, or draining lymph nodes and expanding effector cells in a specific or nonspecific fashion for adoptive transfer. This article describes the rationale for adoptive T-cell therapy, the developments that have led to the translational application of this strategy for the treatment of cancer, the challenges that have been addressed, and future approaches to the development of adoptive therapy as a treatment modality.
AB - Adoptive therapy involves the transfer of ex vivo expanded immune effector cells to patients as a means of augmenting the antitumor immune response. In general, this transfer is accomplished by harvesting cells from the peripheral blood, tumor sites, or draining lymph nodes and expanding effector cells in a specific or nonspecific fashion for adoptive transfer. This article describes the rationale for adoptive T-cell therapy, the developments that have led to the translational application of this strategy for the treatment of cancer, the challenges that have been addressed, and future approaches to the development of adoptive therapy as a treatment modality.
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U2 - 10.1016/j.hoc.2006.02.008
DO - 10.1016/j.hoc.2006.02.008
M3 - Review article
C2 - 16762731
AN - SCOPUS:33744548724
SN - 0889-8588
VL - 20
SP - 711
EP - 733
JO - Hematology/Oncology Clinics of North America
JF - Hematology/Oncology Clinics of North America
IS - 3
ER -