TY - JOUR
T1 - Adriamycin and 1‐(2‐Chlorethyl)‐3‐Cyclohexyl‐1‐Nitrosourea (CCNU) in the treatment of metastatic breast cancer
AU - Waterfield, William C.
AU - Tashima, Charles K.
AU - Hortobagyi, Gabriel N.
AU - Blumenschein, George R.
AU - Buzdar, Aman U.
AU - Burgess, Michael A.
PY - 1978/4
Y1 - 1978/4
N2 - Adriamycin every three weeks and CCNU every six weeks were given to thirty patients with metastatic breast carcinoma. Most patients had received prior chemotherapy. The overall response rate was 40%, with three patients obtaining complete remission. Survival was significantly prolonged in responders versus nonresponders. Three patients developed CNS metastasis while on treatment. Prior chemotherapy was a major factor in determining response rate; all patients without prior chemotherapy responded. The combination appears to be inferior to adriamycin alone in patients who have received prior chemotherapy.
AB - Adriamycin every three weeks and CCNU every six weeks were given to thirty patients with metastatic breast carcinoma. Most patients had received prior chemotherapy. The overall response rate was 40%, with three patients obtaining complete remission. Survival was significantly prolonged in responders versus nonresponders. Three patients developed CNS metastasis while on treatment. Prior chemotherapy was a major factor in determining response rate; all patients without prior chemotherapy responded. The combination appears to be inferior to adriamycin alone in patients who have received prior chemotherapy.
UR - http://www.scopus.com/inward/record.url?scp=0018139492&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0018139492&partnerID=8YFLogxK
U2 - 10.1002/1097-0142(197804)41:4<1235::AID-CNCR2820410403>3.0.CO;2-8
DO - 10.1002/1097-0142(197804)41:4<1235::AID-CNCR2820410403>3.0.CO;2-8
M3 - Article
C2 - 638989
AN - SCOPUS:0018139492
SN - 0008-543X
VL - 41
SP - 1235
EP - 1239
JO - Cancer
JF - Cancer
IS - 4
ER -