TY - JOUR
T1 - Adult acute lymphoblastic leukemia
T2 - Concepts and strategies
AU - Faderl, Stefan
AU - O'Brien, Susan
AU - Pui, Ching Hon
AU - Stock, Wendy
AU - Wetzler, Meir
AU - Hoelzer, Dieter
AU - Kantarjian, Hagop M.
PY - 2010/3/1
Y1 - 2010/3/1
N2 - Acute lymphoblastic leukemia (ALL), a clonal expansion of hematopoietic blasts, is a highly heterogeneous disease comprising many entities for which distinct treatment strategies are pursued. Although ALL is a success story in pediatric oncology, results in adults lag behind those in children. An expansion of new drugs, more reliable immunologic and molecular techniques for the assessment of minimal residual disease, and efforts at more precise risk stratification are generating new aspects of adult ALL therapy. For this review, the authors summarized pertinent and recent literature on ALL biology and therapy, and they discuss current strategies and potential implications of novel approaches to the management of adult ALL.
AB - Acute lymphoblastic leukemia (ALL), a clonal expansion of hematopoietic blasts, is a highly heterogeneous disease comprising many entities for which distinct treatment strategies are pursued. Although ALL is a success story in pediatric oncology, results in adults lag behind those in children. An expansion of new drugs, more reliable immunologic and molecular techniques for the assessment of minimal residual disease, and efforts at more precise risk stratification are generating new aspects of adult ALL therapy. For this review, the authors summarized pertinent and recent literature on ALL biology and therapy, and they discuss current strategies and potential implications of novel approaches to the management of adult ALL.
KW - Acute lymphoblastic leukemia
KW - Cytogenetic and molecular abnormalities
KW - Philadelphia chromosome
KW - Targeted therapy
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U2 - 10.1002/cncr.24862
DO - 10.1002/cncr.24862
M3 - Review article
C2 - 20101737
AN - SCOPUS:77149133679
SN - 0008-543X
VL - 116
SP - 1165
EP - 1176
JO - Cancer
JF - Cancer
IS - 5
ER -