TY - JOUR
T1 - Adult granulosa cell tumors of the ovary in two first-degree relatives
AU - Stevens, Tobey A.
AU - Brown, Jubilee
AU - Zander, Dani S.
AU - Bevers, Michael W.
AU - Gershenson, David M.
AU - Ramondetta, Lois M.
PY - 2005/9
Y1 - 2005/9
N2 - Background. Known inherited mutations are responsible for approximately 10% of all epithelial ovarian cancers; however, prior to this report, sex cord-stromal ovarian tumors had not been documented in related females. Case. We report here on a mother and daughter, each diagnosed with rare, adult-type granulosa cell tumors of the ovary. Conclusion. This novel report of granulosa cell tumors occurring in two first-degree relatives must be examined with reserve. No familial tendency has previously been documented, and our finding may be coincidental. However, if additional cases are reported and future research is undertaken, biological markers and inherited mutations for certain sex cord-stromal ovarian tumors may be identified. These advances could lead to targeted therapy and specific surveillance protocols with appropriate surgical interventions for high-risk patients.
AB - Background. Known inherited mutations are responsible for approximately 10% of all epithelial ovarian cancers; however, prior to this report, sex cord-stromal ovarian tumors had not been documented in related females. Case. We report here on a mother and daughter, each diagnosed with rare, adult-type granulosa cell tumors of the ovary. Conclusion. This novel report of granulosa cell tumors occurring in two first-degree relatives must be examined with reserve. No familial tendency has previously been documented, and our finding may be coincidental. However, if additional cases are reported and future research is undertaken, biological markers and inherited mutations for certain sex cord-stromal ovarian tumors may be identified. These advances could lead to targeted therapy and specific surveillance protocols with appropriate surgical interventions for high-risk patients.
KW - Granulosa cell tumors
KW - Mutations
KW - Sex cord-stromal ovarian tumors
UR - http://www.scopus.com/inward/record.url?scp=23844556153&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=23844556153&partnerID=8YFLogxK
U2 - 10.1016/j.ygyno.2005.04.041
DO - 10.1016/j.ygyno.2005.04.041
M3 - Article
C2 - 15992917
AN - SCOPUS:23844556153
SN - 0090-8258
VL - 98
SP - 502
EP - 505
JO - Gynecologic oncology
JF - Gynecologic oncology
IS - 3
ER -