Adult stem cells and tissue repair

M. Körbling; Z. Estrov; R. Champlin

doi:10.1038/sj.bmt.1703939

Adult stem cells and tissue repair

M. Körbling, Z. Estrov, R. Champlin

Research output: Contribution to journal › Article › peer-review

62 Scopus citations

Abstract

Recently, adult stem cells originating from bone marrow or peripheral blood have been suggested to contribute to repair and genesis of cells specific for liver, cardiac and skeletal muscle, gut, and brain tissue. The mechanism involved has been termed transdifferentiation, although other explanations including cell fusion have been postulated. Using adult stem cells to generate or repair solid organ tissue obviates the immunologic, ethical, and teratogenic issues that accompany embryonic stem cells.

Original language	English (US)
Pages (from-to)	S23-S24
Journal	Bone marrow transplantation
Volume	32
DOIs	https://doi.org/10.1038/sj.bmt.1703939
State	Published - Aug 2003

Keywords

Adult stem cells
Developmental stem cell plasticity
Regenerative medicine
Stem cell transdifferentiation

ASJC Scopus subject areas

Hematology
Transplantation

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10.1038/sj.bmt.1703939

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author = "M. K{\"o}rbling and Z. Estrov and R. Champlin",

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AU - Estrov, Z.

AU - Champlin, R.

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AB - Recently, adult stem cells originating from bone marrow or peripheral blood have been suggested to contribute to repair and genesis of cells specific for liver, cardiac and skeletal muscle, gut, and brain tissue. The mechanism involved has been termed transdifferentiation, although other explanations including cell fusion have been postulated. Using adult stem cells to generate or repair solid organ tissue obviates the immunologic, ethical, and teratogenic issues that accompany embryonic stem cells.

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KW - Developmental stem cell plasticity

KW - Regenerative medicine

KW - Stem cell transdifferentiation

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Adult stem cells and tissue repair

Abstract

Keywords

ASJC Scopus subject areas

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