Adult weight change and risk of colorectal cancer in the European Prospective Investigation into Cancer and Nutrition

Krasimira Aleksandrova; Tobias Pischon; Brian Buijsse; Anne M May; Petra H Peeters; H Bas Bueno-de-Mesquita; Mazda Jenab; Veronika Fedirko; Christina C Dahm; Peter D Siersema; Heinz Freisling; Pietro Ferrari; Kim Overvad; Anne Tjønneland; Antonia Trichopoulou; Pagona Lagiou; Androniki Naska; Valeria Pala; Amalia Mattiello; Bodil Ohlsson; Karin Jirström; Timothy J Key; Kay-Tee Khaw; Elio Riboli; Heiner Boeing

doi:10.1016/j.ejca.2013.06.021

Adult weight change and risk of colorectal cancer in the European Prospective Investigation into Cancer and Nutrition

Krasimira Aleksandrova, Tobias Pischon, Brian Buijsse, Anne M May, Petra H Peeters, H Bas Bueno-de-Mesquita, Mazda Jenab, Veronika Fedirko, Christina C Dahm, Peter D Siersema, Heinz Freisling, Pietro Ferrari, Kim Overvad, Anne Tjønneland, Antonia Trichopoulou, Pagona Lagiou, Androniki Naska, Valeria Pala, Amalia Mattiello, Bodil OhlssonKarin Jirström, Timothy J Key, Kay-Tee Khaw, Elio Riboli, Heiner Boeing

Epidemiology

Research output: Contribution to journal › Article › peer-review

64 Scopus citations

Abstract

AIM: Weight change during adult life may reflect metabolic changes and influence colorectal cancer (CRC) development, but such role is not well established. We aimed to explore the association between adult weight change (from age 20 to 50) and CRC risk. In particular, we investigated differences according to colon and rectal cancer, sex and measures of attained adiposity.

METHODS: We included 201,696 participants from six participating countries in the European Prospective Investigation into Cancer and Nutrition (1992-2010). During a mean follow-up of 11.2 years 2384 (1194 in men and 1190 in women) incident CRC cases occurred. Cox proportional hazard models adjusted for body mass index at age 20 and lifestyle factors at study recruitment were used to calculate hazard ratios (HRs) and 95% confidence intervals (CIs).

RESULTS: After multivariable adjustment, each kg of weight gained annually from age 20 to 50 was associated with a 60% higher risk of colon cancer (95% CI 1.20-2.09), but not rectal cancer (HR 1.13, 95% CI 0.79-1.62, P(interaction)=0.04). The higher risk of colon cancer was restricted to people with high attained waist circumference at age 50 (HR 1.82, 95%CI 1.14-2.91, P(interaction)=0.02). Results were not different in men and women (P(interaction)=0.81).

CONCLUSION(S): Adult weight gain, as reflected by attained abdominal obesity at age 50, increases colon cancer risk in both men and women. These data underline the importance of weight management and metabolic health maintenance in early adult life years for colon cancer prevention.

Original language	English (US)
Pages (from-to)	3526-36
Number of pages	11
Journal	European Journal of Cancer
Volume	49
Issue number	16
DOIs	https://doi.org/10.1016/j.ejca.2013.06.021
State	Published - Nov 2013

Keywords

Adiposity
Adult
Age Factors
Colorectal Neoplasms/diagnosis
Europe/epidemiology
Female
Humans
Incidence
Linear Models
Male
Middle Aged
Multivariate Analysis
Nutritional Status
Obesity, Abdominal/diagnosis
Proportional Hazards Models
Prospective Studies
Risk Assessment
Risk Factors
Risk Reduction Behavior
Time Factors
Waist Circumference
Weight Gain

Access to Document

10.1016/j.ejca.2013.06.021

Cite this

Aleksandrova, K., Pischon, T., Buijsse, B., May, A. M., Peeters, P. H., Bueno-de-Mesquita, H. B., Jenab, M., Fedirko, V., Dahm, C. C., Siersema, P. D., Freisling, H., Ferrari, P., Overvad, K., Tjønneland, A., Trichopoulou, A., Lagiou, P., Naska, A., Pala, V., Mattiello, A., ... Boeing, H. (2013). Adult weight change and risk of colorectal cancer in the European Prospective Investigation into Cancer and Nutrition. European Journal of Cancer, 49(16), 3526-36. https://doi.org/10.1016/j.ejca.2013.06.021

Aleksandrova, K, Pischon, T, Buijsse, B, May, AM, Peeters, PH, Bueno-de-Mesquita, HB, Jenab, M, Fedirko, V, Dahm, CC, Siersema, PD, Freisling, H, Ferrari, P, Overvad, K, Tjønneland, A, Trichopoulou, A, Lagiou, P, Naska, A, Pala, V, Mattiello, A, Ohlsson, B, Jirström, K, Key, TJ, Khaw, K-T, Riboli, E & Boeing, H 2013, 'Adult weight change and risk of colorectal cancer in the European Prospective Investigation into Cancer and Nutrition', European Journal of Cancer, vol. 49, no. 16, pp. 3526-36. https://doi.org/10.1016/j.ejca.2013.06.021

@article{5bd3f95f9e0c4e50a7ef9fb9ef239936,

title = "Adult weight change and risk of colorectal cancer in the European Prospective Investigation into Cancer and Nutrition",

abstract = "AIM: Weight change during adult life may reflect metabolic changes and influence colorectal cancer (CRC) development, but such role is not well established. We aimed to explore the association between adult weight change (from age 20 to 50) and CRC risk. In particular, we investigated differences according to colon and rectal cancer, sex and measures of attained adiposity.METHODS: We included 201,696 participants from six participating countries in the European Prospective Investigation into Cancer and Nutrition (1992-2010). During a mean follow-up of 11.2 years 2384 (1194 in men and 1190 in women) incident CRC cases occurred. Cox proportional hazard models adjusted for body mass index at age 20 and lifestyle factors at study recruitment were used to calculate hazard ratios (HRs) and 95% confidence intervals (CIs).RESULTS: After multivariable adjustment, each kg of weight gained annually from age 20 to 50 was associated with a 60% higher risk of colon cancer (95% CI 1.20-2.09), but not rectal cancer (HR 1.13, 95% CI 0.79-1.62, P(interaction)=0.04). The higher risk of colon cancer was restricted to people with high attained waist circumference at age 50 (HR 1.82, 95%CI 1.14-2.91, P(interaction)=0.02). Results were not different in men and women (P(interaction)=0.81).CONCLUSION(S): Adult weight gain, as reflected by attained abdominal obesity at age 50, increases colon cancer risk in both men and women. These data underline the importance of weight management and metabolic health maintenance in early adult life years for colon cancer prevention.",

keywords = "Adiposity, Adult, Age Factors, Colorectal Neoplasms/diagnosis, Europe/epidemiology, Female, Humans, Incidence, Linear Models, Male, Middle Aged, Multivariate Analysis, Nutritional Status, Obesity, Abdominal/diagnosis, Proportional Hazards Models, Prospective Studies, Risk Assessment, Risk Factors, Risk Reduction Behavior, Time Factors, Waist Circumference, Weight Gain",

author = "Krasimira Aleksandrova and Tobias Pischon and Brian Buijsse and May, {Anne M} and Peeters, {Petra H} and Bueno-de-Mesquita, {H Bas} and Mazda Jenab and Veronika Fedirko and Dahm, {Christina C} and Siersema, {Peter D} and Heinz Freisling and Pietro Ferrari and Kim Overvad and Anne Tj{\o}nneland and Antonia Trichopoulou and Pagona Lagiou and Androniki Naska and Valeria Pala and Amalia Mattiello and Bodil Ohlsson and Karin Jirstr{\"o}m and Key, {Timothy J} and Kay-Tee Khaw and Elio Riboli and Heiner Boeing",

year = "2013",

month = nov,

doi = "10.1016/j.ejca.2013.06.021",

language = "English (US)",

volume = "49",

pages = "3526--36",

journal = "European Journal of Cancer",

issn = "0959-8049",

publisher = "Elsevier Limited",

number = "16",

}

TY - JOUR

T1 - Adult weight change and risk of colorectal cancer in the European Prospective Investigation into Cancer and Nutrition

AU - Aleksandrova, Krasimira

AU - Pischon, Tobias

AU - Buijsse, Brian

AU - May, Anne M

AU - Peeters, Petra H

AU - Bueno-de-Mesquita, H Bas

AU - Jenab, Mazda

AU - Fedirko, Veronika

AU - Dahm, Christina C

AU - Siersema, Peter D

AU - Freisling, Heinz

AU - Ferrari, Pietro

AU - Overvad, Kim

AU - Tjønneland, Anne

AU - Trichopoulou, Antonia

AU - Lagiou, Pagona

AU - Naska, Androniki

AU - Pala, Valeria

AU - Mattiello, Amalia

AU - Ohlsson, Bodil

AU - Jirström, Karin

AU - Key, Timothy J

AU - Khaw, Kay-Tee

AU - Riboli, Elio

AU - Boeing, Heiner

PY - 2013/11

Y1 - 2013/11

N2 - AIM: Weight change during adult life may reflect metabolic changes and influence colorectal cancer (CRC) development, but such role is not well established. We aimed to explore the association between adult weight change (from age 20 to 50) and CRC risk. In particular, we investigated differences according to colon and rectal cancer, sex and measures of attained adiposity.METHODS: We included 201,696 participants from six participating countries in the European Prospective Investigation into Cancer and Nutrition (1992-2010). During a mean follow-up of 11.2 years 2384 (1194 in men and 1190 in women) incident CRC cases occurred. Cox proportional hazard models adjusted for body mass index at age 20 and lifestyle factors at study recruitment were used to calculate hazard ratios (HRs) and 95% confidence intervals (CIs).RESULTS: After multivariable adjustment, each kg of weight gained annually from age 20 to 50 was associated with a 60% higher risk of colon cancer (95% CI 1.20-2.09), but not rectal cancer (HR 1.13, 95% CI 0.79-1.62, P(interaction)=0.04). The higher risk of colon cancer was restricted to people with high attained waist circumference at age 50 (HR 1.82, 95%CI 1.14-2.91, P(interaction)=0.02). Results were not different in men and women (P(interaction)=0.81).CONCLUSION(S): Adult weight gain, as reflected by attained abdominal obesity at age 50, increases colon cancer risk in both men and women. These data underline the importance of weight management and metabolic health maintenance in early adult life years for colon cancer prevention.

AB - AIM: Weight change during adult life may reflect metabolic changes and influence colorectal cancer (CRC) development, but such role is not well established. We aimed to explore the association between adult weight change (from age 20 to 50) and CRC risk. In particular, we investigated differences according to colon and rectal cancer, sex and measures of attained adiposity.METHODS: We included 201,696 participants from six participating countries in the European Prospective Investigation into Cancer and Nutrition (1992-2010). During a mean follow-up of 11.2 years 2384 (1194 in men and 1190 in women) incident CRC cases occurred. Cox proportional hazard models adjusted for body mass index at age 20 and lifestyle factors at study recruitment were used to calculate hazard ratios (HRs) and 95% confidence intervals (CIs).RESULTS: After multivariable adjustment, each kg of weight gained annually from age 20 to 50 was associated with a 60% higher risk of colon cancer (95% CI 1.20-2.09), but not rectal cancer (HR 1.13, 95% CI 0.79-1.62, P(interaction)=0.04). The higher risk of colon cancer was restricted to people with high attained waist circumference at age 50 (HR 1.82, 95%CI 1.14-2.91, P(interaction)=0.02). Results were not different in men and women (P(interaction)=0.81).CONCLUSION(S): Adult weight gain, as reflected by attained abdominal obesity at age 50, increases colon cancer risk in both men and women. These data underline the importance of weight management and metabolic health maintenance in early adult life years for colon cancer prevention.

KW - Adiposity

KW - Adult

KW - Age Factors

KW - Colorectal Neoplasms/diagnosis

KW - Europe/epidemiology

KW - Female

KW - Humans

KW - Incidence

KW - Linear Models

KW - Male

KW - Middle Aged

KW - Multivariate Analysis

KW - Nutritional Status

KW - Obesity, Abdominal/diagnosis

KW - Proportional Hazards Models

KW - Prospective Studies

KW - Risk Assessment

KW - Risk Factors

KW - Risk Reduction Behavior

KW - Time Factors

KW - Waist Circumference

KW - Weight Gain

U2 - 10.1016/j.ejca.2013.06.021

DO - 10.1016/j.ejca.2013.06.021

M3 - Article

C2 - 23867126

SN - 0959-8049

VL - 49

SP - 3526

EP - 3536

JO - European Journal of Cancer

JF - European Journal of Cancer

IS - 16

ER -

Adult weight change and risk of colorectal cancer in the European Prospective Investigation into Cancer and Nutrition

Abstract

Keywords

Access to Document

Fingerprint

Cite this