Advanced carcinoma of the nasopharynx. 2. Pattern of failure in 256 patients

Zbigniew Petrovich; James D. Cox; Robert Middleton; Maimu Ohanian; Camilo Paig; Joanne Jepson

doi:10.1016/S0167-8140(85)80057-8

Advanced carcinoma of the nasopharynx. 2. Pattern of failure in 256 patients

Zbigniew Petrovich, James D. Cox, Robert Middleton, Maimu Ohanian, Camilo Paig, Joanne Jepson

Radiation Oncology

Research output: Contribution to journal › Article › peer-review

35 Scopus citations

Abstract

Of 256 patients with advanced carcinoma of the nasopharynx, 82% presented with Stage IV disease. The 5-year survival was 15% with 83% failing within 2 years. Prognosis was related to stage (p<0.003), neck status (p<0.03), initial performance status (p<0.001) and radiation dose (p<0.003). With no pathological neck glands (N₀), less than 5% failed radiotherapy. Overall, 36% had distant metastases, correlating with the N Stage (p<0.001) but not with the T Stage. The most frequent site of metastasis was lung, then bone and liver. Radical neck dissection failed to increase tumor control, contributing to three fatal complications. New radiotherapeutic regimens have so far failed to substantially improve the results.

Original language	English (US)
Pages (from-to)	15-20
Number of pages	6
Journal	Radiotherapy and Oncology
Volume	4
Issue number	1
DOIs	https://doi.org/10.1016/S0167-8140(85)80057-8
State	Published - Aug 1985

Keywords

Advanced carcinoma nasopharynx
Pattern of failure
Radiotherapy

ASJC Scopus subject areas

Hematology
Oncology
Radiology Nuclear Medicine and imaging

Access to Document

10.1016/S0167-8140(85)80057-8

Cite this

@article{440160a705574c20847faea4a26d0d10,

title = "Advanced carcinoma of the nasopharynx. 2. Pattern of failure in 256 patients",

abstract = "Of 256 patients with advanced carcinoma of the nasopharynx, 82% presented with Stage IV disease. The 5-year survival was 15% with 83% failing within 2 years. Prognosis was related to stage (p<0.003), neck status (p<0.03), initial performance status (p<0.001) and radiation dose (p<0.003). With no pathological neck glands (N0), less than 5% failed radiotherapy. Overall, 36% had distant metastases, correlating with the N Stage (p<0.001) but not with the T Stage. The most frequent site of metastasis was lung, then bone and liver. Radical neck dissection failed to increase tumor control, contributing to three fatal complications. New radiotherapeutic regimens have so far failed to substantially improve the results.",

keywords = "Advanced carcinoma nasopharynx, Pattern of failure, Radiotherapy",

author = "Zbigniew Petrovich and Cox, {James D.} and Robert Middleton and Maimu Ohanian and Camilo Paig and Joanne Jepson",

year = "1985",

month = aug,

doi = "10.1016/S0167-8140(85)80057-8",

language = "English (US)",

volume = "4",

pages = "15--20",

journal = "Radiotherapy and Oncology",

issn = "0167-8140",

publisher = "Elsevier Ireland Ltd",

number = "1",

}

TY - JOUR

T1 - Advanced carcinoma of the nasopharynx. 2. Pattern of failure in 256 patients

AU - Petrovich, Zbigniew

AU - Cox, James D.

AU - Middleton, Robert

AU - Ohanian, Maimu

AU - Paig, Camilo

AU - Jepson, Joanne

PY - 1985/8

Y1 - 1985/8

N2 - Of 256 patients with advanced carcinoma of the nasopharynx, 82% presented with Stage IV disease. The 5-year survival was 15% with 83% failing within 2 years. Prognosis was related to stage (p<0.003), neck status (p<0.03), initial performance status (p<0.001) and radiation dose (p<0.003). With no pathological neck glands (N0), less than 5% failed radiotherapy. Overall, 36% had distant metastases, correlating with the N Stage (p<0.001) but not with the T Stage. The most frequent site of metastasis was lung, then bone and liver. Radical neck dissection failed to increase tumor control, contributing to three fatal complications. New radiotherapeutic regimens have so far failed to substantially improve the results.

AB - Of 256 patients with advanced carcinoma of the nasopharynx, 82% presented with Stage IV disease. The 5-year survival was 15% with 83% failing within 2 years. Prognosis was related to stage (p<0.003), neck status (p<0.03), initial performance status (p<0.001) and radiation dose (p<0.003). With no pathological neck glands (N0), less than 5% failed radiotherapy. Overall, 36% had distant metastases, correlating with the N Stage (p<0.001) but not with the T Stage. The most frequent site of metastasis was lung, then bone and liver. Radical neck dissection failed to increase tumor control, contributing to three fatal complications. New radiotherapeutic regimens have so far failed to substantially improve the results.

KW - Advanced carcinoma nasopharynx

KW - Pattern of failure

KW - Radiotherapy

UR - http://www.scopus.com/inward/record.url?scp=0021800833&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0021800833&partnerID=8YFLogxK

U2 - 10.1016/S0167-8140(85)80057-8

DO - 10.1016/S0167-8140(85)80057-8

M3 - Article

C2 - 4034999

AN - SCOPUS:0021800833

SN - 0167-8140

VL - 4

SP - 15

EP - 20

JO - Radiotherapy and Oncology

JF - Radiotherapy and Oncology

IS - 1

ER -

Advanced carcinoma of the nasopharynx. 2. Pattern of failure in 256 patients

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this