TY - JOUR
T1 - Advances in magnetic resonance imaging and positron emission tomography imaging for grading and molecular characterization of glioma
AU - Chung, Caroline
AU - Metser, Ur
AU - Ménard, Cynthia
N1 - Publisher Copyright:
© 2015 Elsevier Inc.
PY - 2015
Y1 - 2015
N2 - In recent years, the management of glioma has evolved significantly, reflecting our better understanding of the underlying mechanisms of tumor development, tumor progression, and treatment response. Glioma grade, along with a number of underlying molecular and genetic biomarkers, has been recognized as an important prognostic and predictive factor that can help guide the management of patients. This article highlights advances in magnetic resonance imaging (MRI), including diffusion-weighted imaging, diffusion tensor imaging, magnetic resonance spectroscopy, dynamic contrast-enhanced imaging, and perfusion MRI, as well as position emission tomography using various tracers including methyl-11C-l-methionine and O-(2-18F-fluoroethyl)-l-tyrosine. Use of multiparametric imaging data has improved the diagnostic strength of imaging, introduced the potential to noninvasively interrogate underlying molecular features of low-grade glioma and to guide local therapies such as surgery and radiotherapy.
AB - In recent years, the management of glioma has evolved significantly, reflecting our better understanding of the underlying mechanisms of tumor development, tumor progression, and treatment response. Glioma grade, along with a number of underlying molecular and genetic biomarkers, has been recognized as an important prognostic and predictive factor that can help guide the management of patients. This article highlights advances in magnetic resonance imaging (MRI), including diffusion-weighted imaging, diffusion tensor imaging, magnetic resonance spectroscopy, dynamic contrast-enhanced imaging, and perfusion MRI, as well as position emission tomography using various tracers including methyl-11C-l-methionine and O-(2-18F-fluoroethyl)-l-tyrosine. Use of multiparametric imaging data has improved the diagnostic strength of imaging, introduced the potential to noninvasively interrogate underlying molecular features of low-grade glioma and to guide local therapies such as surgery and radiotherapy.
UR - http://www.scopus.com/inward/record.url?scp=84943147944&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84943147944&partnerID=8YFLogxK
U2 - 10.1016/j.semradonc.2015.02.002
DO - 10.1016/j.semradonc.2015.02.002
M3 - Review article
C2 - 26050586
AN - SCOPUS:84943147944
SN - 1053-4296
VL - 25
SP - 164
EP - 171
JO - Seminars in radiation oncology
JF - Seminars in radiation oncology
IS - 3
ER -