TY - JOUR
T1 - Advances in the development of cancer immunotherapies
AU - Gao, Jianjun
AU - Bernatchez, Chantale
AU - Sharma, Padmanee
AU - Radvanyi, Laszlo G.
AU - Hwu, Patrick
PY - 2013/2
Y1 - 2013/2
N2 - Manipulating the immune system in order to induce clinically relevant responses against cancer is a longstanding goal. Interventions to enhance tumor-specific immunity through vaccination, sustaining effector T cell activation, or increasing the numbers of tumor-specific T cells using ex vivo expansion, have all resulted in clinical successes. Here, we examine recent clinical advances and major ongoing studies in the field of cancer immunotherapy. Single agents have so far benefited a limited proportion of patients, and future studies combining different types of immunotherapies and other therapeutic modalities, such as drugs against specific signaling pathways driving cancer cell growth, are needed to pave the way for the development of effective anticancer treatments causing durable responses.
AB - Manipulating the immune system in order to induce clinically relevant responses against cancer is a longstanding goal. Interventions to enhance tumor-specific immunity through vaccination, sustaining effector T cell activation, or increasing the numbers of tumor-specific T cells using ex vivo expansion, have all resulted in clinical successes. Here, we examine recent clinical advances and major ongoing studies in the field of cancer immunotherapy. Single agents have so far benefited a limited proportion of patients, and future studies combining different types of immunotherapies and other therapeutic modalities, such as drugs against specific signaling pathways driving cancer cell growth, are needed to pave the way for the development of effective anticancer treatments causing durable responses.
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U2 - 10.1016/j.it.2012.08.004
DO - 10.1016/j.it.2012.08.004
M3 - Review article
C2 - 23031830
AN - SCOPUS:84873124622
SN - 1471-4906
VL - 34
SP - 90
EP - 98
JO - Trends in Immunology
JF - Trends in Immunology
IS - 2
ER -