Advances in the Management of Pediatric Sarcomas

Fiorela N. Hernandez Tejada, Alejandro Zamudio, Mario L. Marques-Piubelli, Branko Cuglievan, Douglas Harrison

Research output: Contribution to journalReview articlepeer-review


Purpose of Review: The prognosis of pediatric patients who present with metastatic or recurrent sarcomas remains poor. In this review, we summarize the advances in the management of metastatic and relapsed pediatric sarcoma by highlighting recent and future clinical trials. Recent Findings: Research into the identification of novel therapies for refractory pediatric sarcomas continues to advance. Outcomes have not improved in several decades underlying a need for improved understanding of the biology behind these tumors and the identification of novel therapeutic molecular targets that can be exploited pharmacologically. Multiple challenges remain for novel therapy in sarcomas such as the selection of effective targets, management of toxicities, and the tumor microenvironment. Summary: Many unique challenges remain in the treatment of patients with refractory pediatric sarcomas. Multiple strategies and targets are under investigation that hold promise.

Original languageEnglish (US)
Article number3
JournalCurrent oncology reports
Issue number1
StatePublished - Jan 2021


  • Immunotherapy
  • Pediatric sarcomas
  • Sarcomas
  • Therapy

ASJC Scopus subject areas

  • Oncology

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