TY - JOUR
T1 - Advances in the pathologic diagnosis and biology of acute myeloid leukemia
AU - Konoplev, Sergej
AU - Bueso-Ramos, Carlos E.
PY - 2006/2
Y1 - 2006/2
N2 - In a general surgical pathology practice, cases of acute myeloid leukemia (AML), including myeloid sarcoma, are relatively rare; the diagnosis is very often difficult, however, and consequences of a missed or improper diagnosis compromise patient care. Currently, accurate diagnosis of every case of AML requires integration of the morphological features and results of cytochemical and immunohistochemical stains, flow cytometric immunophenotyping, cytogenetics, and molecular studies. This review focuses on a practical approach to diagnosis of AML according to current standard of practice and discusses some of recent changes in the field of AML.
AB - In a general surgical pathology practice, cases of acute myeloid leukemia (AML), including myeloid sarcoma, are relatively rare; the diagnosis is very often difficult, however, and consequences of a missed or improper diagnosis compromise patient care. Currently, accurate diagnosis of every case of AML requires integration of the morphological features and results of cytochemical and immunohistochemical stains, flow cytometric immunophenotyping, cytogenetics, and molecular studies. This review focuses on a practical approach to diagnosis of AML according to current standard of practice and discusses some of recent changes in the field of AML.
KW - Acute myeloid leukemia
KW - Cytogenetics
KW - Molecular
KW - Myeloid sarcoma
UR - http://www.scopus.com/inward/record.url?scp=30644468502&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=30644468502&partnerID=8YFLogxK
U2 - 10.1016/j.anndiagpath.2005.10.001
DO - 10.1016/j.anndiagpath.2005.10.001
M3 - Review article
C2 - 16414545
AN - SCOPUS:30644468502
SN - 1092-9134
VL - 10
SP - 39
EP - 65
JO - Annals of Diagnostic Pathology
JF - Annals of Diagnostic Pathology
IS - 1
ER -