TY - JOUR
T1 - Advancing treatment for metastatic bone cancer
T2 - Consensus recommendations from the second cambridge conference
AU - Coleman, Robert E.
AU - Guise, Theresa A.
AU - Lipton, Allan
AU - Roodman, G. David
AU - Berenson, James R.
AU - Body, Jean Jacques
AU - Boyce, Brendan F.
AU - Calvi, Laura M.
AU - Hadji, Peyman
AU - McCloskey, Eugene V.
AU - Saad, Fred
AU - Smith, Matthew R.
AU - Suva, Larry J.
AU - Taichman, Russell S.
AU - Vessella, Robert L.
AU - Weilbaecher, Katherine N.
PY - 2008/10/15
Y1 - 2008/10/15
N2 - Purpose: Summarize current knowledge, critical gaps in knowledge, and recommendations to advance the field of metastatic bone cancer. Experimental Design: A multidisciplinary consensus conference was convened to review recent progress in basic and clinical research, assess critical gaps in current knowledge, and prioritize recommendations to advance research in the next 5 years. The program addressed three principal topics: biology of metastasis, preserving normal bone health, and optimizing bone-targeted therapies. Results: A variety of specific recommendations were identified as important to advance research and clinical care over the next 5 years. Conclusions: Priorities for research in bone biology include characterizing components of the stem cell niche in bone, developing oncogenic immunocompetent animal models of bone metastasis, and investigating the unique contribution of the bone microenvironment to tumor growth and dormancy. Priorities for research in preserving normal bone health include developing methods to measure and characterize disseminating tumor cells, assessing outcomes from the major prevention trials currently in progress, and improving methodologies to assess risks and benefits of treatment. Priorities for optimizing bone-targeted therapies include advancing studies of serum proteomics and genomics to reliably identify patients who will develop bone metastases, enhancing imaging for early detection of bone metastases and early response evaluation, and developing new tests to evaluate response to bone-directed treatments.
AB - Purpose: Summarize current knowledge, critical gaps in knowledge, and recommendations to advance the field of metastatic bone cancer. Experimental Design: A multidisciplinary consensus conference was convened to review recent progress in basic and clinical research, assess critical gaps in current knowledge, and prioritize recommendations to advance research in the next 5 years. The program addressed three principal topics: biology of metastasis, preserving normal bone health, and optimizing bone-targeted therapies. Results: A variety of specific recommendations were identified as important to advance research and clinical care over the next 5 years. Conclusions: Priorities for research in bone biology include characterizing components of the stem cell niche in bone, developing oncogenic immunocompetent animal models of bone metastasis, and investigating the unique contribution of the bone microenvironment to tumor growth and dormancy. Priorities for research in preserving normal bone health include developing methods to measure and characterize disseminating tumor cells, assessing outcomes from the major prevention trials currently in progress, and improving methodologies to assess risks and benefits of treatment. Priorities for optimizing bone-targeted therapies include advancing studies of serum proteomics and genomics to reliably identify patients who will develop bone metastases, enhancing imaging for early detection of bone metastases and early response evaluation, and developing new tests to evaluate response to bone-directed treatments.
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U2 - 10.1158/1078-0432.CCR-08-1572
DO - 10.1158/1078-0432.CCR-08-1572
M3 - Review article
C2 - 18927277
AN - SCOPUS:58149179539
SN - 1078-0432
VL - 14
SP - 6387
EP - 6395
JO - Clinical Cancer Research
JF - Clinical Cancer Research
IS - 20
ER -