TY - JOUR
T1 - Aerosolized amphotericin B-liposomes for treatment of systemic Candida infections in mice
AU - Gilbert, B. E.
AU - Wyde, P. R.
AU - Lopez-Berestein, G.
AU - Wilson, S. Z.
PY - 1994
Y1 - 1994
N2 - Mice lethally infected with Candida albicans were exposed to small- particle aerosols containing amphotericin B-liposomes. The drug, when administered twice daily for 2 h (0.58 mg/kg of body weight per day) on days 1, 2, and 3 postinoculation, significantly reduced the numbers of Candida organisms in the kidneys. Aerosol treatment increased the survival time of mice given 2 2-h treatments once a week for 4 weeks. A twice-weekly, 2-h small-particle aerosol administration of amphotericin B-liposomes for 1, 2, or 3 weeks significantly increased both the mean time of survival and percent survival.
AB - Mice lethally infected with Candida albicans were exposed to small- particle aerosols containing amphotericin B-liposomes. The drug, when administered twice daily for 2 h (0.58 mg/kg of body weight per day) on days 1, 2, and 3 postinoculation, significantly reduced the numbers of Candida organisms in the kidneys. Aerosol treatment increased the survival time of mice given 2 2-h treatments once a week for 4 weeks. A twice-weekly, 2-h small-particle aerosol administration of amphotericin B-liposomes for 1, 2, or 3 weeks significantly increased both the mean time of survival and percent survival.
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U2 - 10.1128/AAC.38.2.356
DO - 10.1128/AAC.38.2.356
M3 - Comment/debate
C2 - 8192464
AN - SCOPUS:0028009372
SN - 0066-4804
VL - 38
SP - 356
EP - 359
JO - Antimicrobial agents and chemotherapy
JF - Antimicrobial agents and chemotherapy
IS - 2
ER -