African Americans with translocation t(11;14) have superior survival after autologous hematopoietic cell transplantation for multiple myeloma in comparison with Whites in the United States

Talha Badar, Parameswaran Hari, Omar Dávila, Raphael Fraser, Baldeep Wirk, Binod Dhakal, Cesar O. Freytes, Cesar Rodriguez Valdes, Cindy Lee, David H. Vesole, Ehsan Malek, Gerhard C. Hildebrandt, Heather Landau, Hemant S. Murthy, Hillard M. Lazarus, Jesus G. Berdeja, Kenneth R. Meehan, Melhem Solh, Miguel Angel Diaz, Mohamed A. Kharfan-DabajaNatalie S. Callander, Nosha Farhadfar, Qaiser Bashir, Rammurti T. Kamble, Ravi Vij, Reinhold Munker, Robert A. Kyle, Saurabh Chhabra, Shahrukh Hashmi, Siddhartha Ganguly, Sundar Jagannath, Taiga Nishihori, Yago Nieto, Shaji Kumar, Nina Das Shah, Anita D’Souza

Research output: Contribution to journalArticlepeer-review

1 Scopus citations

Abstract

Background: Multiple myeloma (MM) with the translocation t(11;14) may have inferior outcomes in comparison with other standard-risk MM, and it has been suggested to portend a worse prognosis in African Americans in comparison with Whites. This study used the Center for International Blood and Marrow Transplant Research (CIBMTR) database to examine the impact of t(11;14) on the clinical outcomes of patients with MM of African American and White descent. Methods: This study evaluated 3538 patients who underwent autologous hematopoietic cell transplantation (autoHCT) for MM from 2008 to 2016 and were reported to the CIBMTR. Patients were analyzed in 4 groups: African Americans with t(11;14) (n = 117), African Americans without t(11;14) (n = 968), Whites with t(11;14) (n = 266), and Whites without t(11;14) (n = 2187). Results: African Americans with t(11;14) were younger, had lower Karnofsky scores, and had more advanced stage MM with a higher Hematopoietic Cell Transplantation–Comorbidity Index (HCT-CI). Fewer African Americans with t(11;14) (21%) had a coexistent high-risk marker in comparison with Whites with t(11;14) (27%). In a multivariate analysis, race and t(11;14) had no association with progression-free survival. However, overall survival was superior among African Americans with t(11;14) in comparison with Whites with t(11;14) (hazard ratio, 0.53; 95% confidence interval, 0.30-0.93; P =.03). Survival was also associated with female sex, stage, time from diagnosis to transplant, a low HCT-CI, and receipt of maintenance. Conclusions: Race may have a differential impact on the survival of patients with t(11;14) MM who undergo autoHCT and needs to be further studied.

Original languageEnglish (US)
JournalCancer
DOIs
StateAccepted/In press - 2020

Keywords

  • myeloma
  • outcomes
  • race
  • t(11;14)
  • transplant

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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