TY - JOUR
T1 - Ag-NOR studies in a human lymphocyte culture
T2 - Are variants localized to specific chromosomes?
AU - Ozen, M.
AU - Hopwood, V. L.
AU - Pathak, S.
PY - 1995
Y1 - 1995
N2 - The genomic activity and polymorphisms of nucleolus organizer regions (NORs) were studied in an individual with routinely used AgNO3 and Q- banding techniques. The results demonstrate that (a) the mean number of NORs per metaphase spread was 7.4, (b) chromosomes 14, 13, 15, and 21 showed variations of Ag-NOR in decreasing order, (c) chromosome 22 did not show a polymorphism in any cell examined, and (d) both chromosomes 14 showed silver staining in most cells. Unlike many earlier reports indicating that NOR variants were constitutional in each individual, our present case represented a mosaic pattern of polymorphism involving most of the D- and G-group chromosomes.
AB - The genomic activity and polymorphisms of nucleolus organizer regions (NORs) were studied in an individual with routinely used AgNO3 and Q- banding techniques. The results demonstrate that (a) the mean number of NORs per metaphase spread was 7.4, (b) chromosomes 14, 13, 15, and 21 showed variations of Ag-NOR in decreasing order, (c) chromosome 22 did not show a polymorphism in any cell examined, and (d) both chromosomes 14 showed silver staining in most cells. Unlike many earlier reports indicating that NOR variants were constitutional in each individual, our present case represented a mosaic pattern of polymorphism involving most of the D- and G-group chromosomes.
KW - metaphase
KW - mosaic pattern
KW - variants
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U2 - 10.1002/ajmg.1320590220
DO - 10.1002/ajmg.1320590220
M3 - Article
C2 - 8588590
AN - SCOPUS:0028875673
SN - 0148-7299
VL - 59
SP - 225
EP - 228
JO - American journal of medical genetics
JF - American journal of medical genetics
IS - 2
ER -