Age-related cognitive impairment is associated with low serum concentrations of testosterone and CSF levels of amyloid beta 42 in male cynomolgus monkeys (Macaca fascicularis)

Huda Shalahudin Darusman; Tan Li Wern; Dondin Sajuthi; Steven J. Schapiro; Jann Hau

doi:10.1111/jmp.12536

Age-related cognitive impairment is associated with low serum concentrations of testosterone and CSF levels of amyloid beta 42 in male cynomolgus monkeys (Macaca fascicularis)

Huda Shalahudin Darusman, Tan Li Wern, Dondin Sajuthi, Steven J. Schapiro, Jann Hau

Comparative Medicine

Research output: Contribution to journal › Article › peer-review

Abstract

Aged memory-impaired cynomolgus monkeys had significantly lower levels of cerebrospinal amyloid (Aβ₄₂) and serum testosterone compared with young animals and non–memory-impaired controls. Our findings confirm similar findings in the human and substantiate the usefulness of the cynomolgus monkey as a spontaneous model for aging-associated senile dementia of the Alzheimer type.

Original language	English (US)
Pages (from-to)	270-272
Number of pages	3
Journal	Journal of medical primatology
Volume	50
Issue number	5
DOIs	https://doi.org/10.1111/jmp.12536
State	Published - Oct 2021

Keywords

aging
animal model
cognitive
non-human primates
sex hormone

ASJC Scopus subject areas

Animal Science and Zoology
General Veterinary

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10.1111/jmp.12536

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Age-related cognitive impairment is associated with low serum concentrations of testosterone and CSF levels of amyloid beta 42 in male cynomolgus monkeys (Macaca fascicularis). / Darusman, Huda Shalahudin; Li Wern, Tan; Sajuthi, Dondin et al.
In: Journal of medical primatology, Vol. 50, No. 5, 10.2021, p. 270-272.

Research output: Contribution to journal › Article › peer-review

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AU - Schapiro, Steven J.

AU - Hau, Jann

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Age-related cognitive impairment is associated with low serum concentrations of testosterone and CSF levels of amyloid beta 42 in male cynomolgus monkeys (Macaca fascicularis)

Abstract

Keywords

ASJC Scopus subject areas

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