ALK signaling and target therapy in anaplastic large cell lymphoma

Fabrizio Tabbó; Antonella Barreca; Roberto Piva; Giorgio Inghirami; Riccardo Bruna; Daniele Corino; Diego Cortese; Ramona Crescenzo; Giuditta Cuccuru; Filomena di Giacomo; Alessandro Fioravanti; Marco Ladetto; Indira Landra; Katia Messana; Rodolfo Machiorlatti; Barbara Martinoglio; Enzo Medico; Marta Mossino; Elisa Pellegrino; Maria Todaro; Paola Campisi; Luigi Chiusa Annalisa Chiappella; Domenico Novero; Umberto Vitolo; Francesco Abate; Andrea Acquaviva; Elisa Ficarra; Roberto Freilone; Marco Chilosi; Alberto Zamó; Fabio Facchetti; Silvia Lonardi; Anna De Chiara; Franco Fulciniti; Claudio Doglioni; Maurilio Ponzoni; Luca Agnelli; Antonino Neri; Katia Todoerti; Claudio Agostinelli; Pier Paolo Piccaluga; Stefano Pileri; Brunangelo Falini; Enrico Tiacci; Peter Van Loo; Thomas Tousseyn; Christiane De Wolf-Peeters; Eva Geissinger; Hans Konrad Muller-Hermelink; Andreas Rosenwald; Miguel Angel Pirisand Maria E. Rodriguez; Francesco Bertoni; Michela Boi; Ivo Kwee

doi:10.3389/fonc.2012.00041

ALK signaling and target therapy in anaplastic large cell lymphoma

Fabrizio Tabbó, Antonella Barreca, Roberto Piva, Giorgio Inghirami, Riccardo Bruna, Daniele Corino, Diego Cortese, Ramona Crescenzo, Giuditta Cuccuru, Filomena di Giacomo, Alessandro Fioravanti, Marco Ladetto, Indira Landra, Katia Messana, Rodolfo Machiorlatti, Barbara Martinoglio, Enzo Medico, Marta Mossino, Elisa Pellegrino, Maria TodaroPaola Campisi, Luigi Chiusa Annalisa Chiappella, Domenico Novero, Umberto Vitolo, Francesco Abate, Andrea Acquaviva, Elisa Ficarra, Roberto Freilone, Marco Chilosi, Alberto Zamó, Fabio Facchetti, Silvia Lonardi, Anna De Chiara, Franco Fulciniti, Claudio Doglioni, Maurilio Ponzoni, Luca Agnelli, Antonino Neri, Katia Todoerti, Claudio Agostinelli, Pier Paolo Piccaluga, Stefano Pileri, Brunangelo Falini, Enrico Tiacci, Peter Van Loo, Thomas Tousseyn, Christiane De Wolf-Peeters, Eva Geissinger, Hans Konrad Muller-Hermelink, Andreas Rosenwald, Miguel Angel Pirisand Maria E. Rodriguez, Francesco Bertoni, Michela Boi, Ivo Kwee

Research output: Contribution to journal › Review article › peer-review

40 Scopus citations

Abstract

The discovery by Morris et al. (1994) of the genes contributing to the t(2;5)(p23;q35) translocation has laid the foundation for a molecular based recognition of anaplastic large cell lymphoma and highlighted the need for a further stratification of T-cell neoplasia. Likewise the detection of anaplastic lymphoma kinase (ALK) genetic lesions among many human cancers has defined unique subsets of cancer patients, providing new opportunities for innovative therapeutic interventions. The objective of this review is to appraise the molecular mechanisms driving ALK-mediated transformation, and to maintain the neoplastic phenotype. The understanding of these events will allow the design and implementation of novel tailored strategies for a well-defined subset of cancer patients.

Original language	English (US)
Article number	Article 41
Journal	Frontiers in Oncology
Volume	2 MAY
DOIs	https://doi.org/10.3389/fonc.2012.00041
State	Published - 2012
Externally published	Yes

Keywords

Anaplastic large cell lymphoma
Anaplastic lymphoma kinase
Chimeric fusion proteins
Molecular targeted therapy
Signaling pathways

ASJC Scopus subject areas

Oncology
Cancer Research

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10.3389/fonc.2012.00041

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Tabbó, F., Barreca, A., Piva, R., Inghirami, G., Bruna, R., Corino, D., Cortese, D., Crescenzo, R., Cuccuru, G., di Giacomo, F., Fioravanti, A., Ladetto, M., Landra, I., Messana, K., Machiorlatti, R., Martinoglio, B., Medico, E., Mossino, M., Pellegrino, E., ... Kwee, I. (2012). ALK signaling and target therapy in anaplastic large cell lymphoma. Frontiers in Oncology, 2 MAY, Article Article 41. https://doi.org/10.3389/fonc.2012.00041

Tabbó, F, Barreca, A, Piva, R, Inghirami, G, Bruna, R, Corino, D, Cortese, D, Crescenzo, R, Cuccuru, G, di Giacomo, F, Fioravanti, A, Ladetto, M, Landra, I, Messana, K, Machiorlatti, R, Martinoglio, B, Medico, E, Mossino, M, Pellegrino, E, Todaro, M, Campisi, P, Chiappella, LCA, Novero, D, Vitolo, U, Abate, F, Acquaviva, A, Ficarra, E, Freilone, R, Chilosi, M, Zamó, A, Facchetti, F, Lonardi, S, De Chiara, A, Fulciniti, F, Doglioni, C, Ponzoni, M, Agnelli, L, Neri, A, Todoerti, K, Agostinelli, C, Piccaluga, PP, Pileri, S, Falini, B, Tiacci, E, Van Loo, P, Tousseyn, T, De Wolf-Peeters, C, Geissinger, E, Muller-Hermelink, HK, Rosenwald, A, Rodriguez, MAPME, Bertoni, F, Boi, M & Kwee, I 2012, 'ALK signaling and target therapy in anaplastic large cell lymphoma', Frontiers in Oncology, vol. 2 MAY, Article 41. https://doi.org/10.3389/fonc.2012.00041

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title = "ALK signaling and target therapy in anaplastic large cell lymphoma",

abstract = "The discovery by Morris et al. (1994) of the genes contributing to the t(2;5)(p23;q35) translocation has laid the foundation for a molecular based recognition of anaplastic large cell lymphoma and highlighted the need for a further stratification of T-cell neoplasia. Likewise the detection of anaplastic lymphoma kinase (ALK) genetic lesions among many human cancers has defined unique subsets of cancer patients, providing new opportunities for innovative therapeutic interventions. The objective of this review is to appraise the molecular mechanisms driving ALK-mediated transformation, and to maintain the neoplastic phenotype. The understanding of these events will allow the design and implementation of novel tailored strategies for a well-defined subset of cancer patients.",

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AU - Tabbó, Fabrizio

AU - Barreca, Antonella

AU - Piva, Roberto

AU - Inghirami, Giorgio

AU - Bruna, Riccardo

AU - Corino, Daniele

AU - Cortese, Diego

AU - Crescenzo, Ramona

AU - Cuccuru, Giuditta

AU - di Giacomo, Filomena

AU - Fioravanti, Alessandro

AU - Ladetto, Marco

AU - Landra, Indira

AU - Messana, Katia

AU - Machiorlatti, Rodolfo

AU - Martinoglio, Barbara

AU - Medico, Enzo

AU - Mossino, Marta

AU - Pellegrino, Elisa

AU - Todaro, Maria

AU - Campisi, Paola

AU - Chiappella, Luigi Chiusa Annalisa

AU - Novero, Domenico

AU - Vitolo, Umberto

AU - Abate, Francesco

AU - Acquaviva, Andrea

AU - Ficarra, Elisa

AU - Freilone, Roberto

AU - Chilosi, Marco

AU - Zamó, Alberto

AU - Facchetti, Fabio

AU - Lonardi, Silvia

AU - De Chiara, Anna

AU - Fulciniti, Franco

AU - Doglioni, Claudio

AU - Ponzoni, Maurilio

AU - Agnelli, Luca

AU - Neri, Antonino

AU - Todoerti, Katia

AU - Agostinelli, Claudio

AU - Piccaluga, Pier Paolo

AU - Pileri, Stefano

AU - Falini, Brunangelo

AU - Tiacci, Enrico

AU - Van Loo, Peter

AU - Tousseyn, Thomas

AU - De Wolf-Peeters, Christiane

AU - Geissinger, Eva

AU - Muller-Hermelink, Hans Konrad

AU - Rosenwald, Andreas

AU - Rodriguez, Miguel Angel Pirisand Maria E.

AU - Bertoni, Francesco

AU - Boi, Michela

AU - Kwee, Ivo

PY - 2012

Y1 - 2012

N2 - The discovery by Morris et al. (1994) of the genes contributing to the t(2;5)(p23;q35) translocation has laid the foundation for a molecular based recognition of anaplastic large cell lymphoma and highlighted the need for a further stratification of T-cell neoplasia. Likewise the detection of anaplastic lymphoma kinase (ALK) genetic lesions among many human cancers has defined unique subsets of cancer patients, providing new opportunities for innovative therapeutic interventions. The objective of this review is to appraise the molecular mechanisms driving ALK-mediated transformation, and to maintain the neoplastic phenotype. The understanding of these events will allow the design and implementation of novel tailored strategies for a well-defined subset of cancer patients.

AB - The discovery by Morris et al. (1994) of the genes contributing to the t(2;5)(p23;q35) translocation has laid the foundation for a molecular based recognition of anaplastic large cell lymphoma and highlighted the need for a further stratification of T-cell neoplasia. Likewise the detection of anaplastic lymphoma kinase (ALK) genetic lesions among many human cancers has defined unique subsets of cancer patients, providing new opportunities for innovative therapeutic interventions. The objective of this review is to appraise the molecular mechanisms driving ALK-mediated transformation, and to maintain the neoplastic phenotype. The understanding of these events will allow the design and implementation of novel tailored strategies for a well-defined subset of cancer patients.

KW - Anaplastic large cell lymphoma

KW - Anaplastic lymphoma kinase

KW - Chimeric fusion proteins

KW - Molecular targeted therapy

KW - Signaling pathways

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U2 - 10.3389/fonc.2012.00041

DO - 10.3389/fonc.2012.00041

M3 - Review article

C2 - 22649787

AN - SCOPUS:84872363571

SN - 2234-943X

VL - 2 MAY

JO - Frontiers in Oncology

JF - Frontiers in Oncology

M1 - Article 41

ER -

ALK signaling and target therapy in anaplastic large cell lymphoma

Abstract

Keywords

ASJC Scopus subject areas

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