Alkyltransferase-like proteins: Molecular switches between DNA repair pathways

Julie L. Tubbs; John A. Tainer

doi:10.1007/s00018-010-0405-8

Alkyltransferase-like proteins: Molecular switches between DNA repair pathways

Julie L. Tubbs, John A. Tainer

Research output: Contribution to journal › Review article › peer-review

22 Scopus citations

Abstract

Alkyltransferase-like proteins (ATLs) play a role in the protection of cells from the biological effects of DNA alkylation damage. Although ATLs share functional motifs with the DNA repair protein and cancer chemotherapy target O ⁶-alkylguanine-DNA alkyltransferase, they lack the reactive cysteine residue required for alkyltransferase activity, so its mechanism for cell protection was previously unknown. Here we review recent advances in unraveling the enigmatic cellular protection provided by ATLs against the deleterious effects of DNA alkylation damage. We discuss exciting new evidence that ATLs aid in the repair of DNA O ⁶-alkylguanine lesions through a novel repair cross-talk between DNA-alkylation base damage responses and the DNA nucleotide excision repair pathway.

Original language	English (US)
Pages (from-to)	3749-3762
Number of pages	14
Journal	Cellular and Molecular Life Sciences
Volume	67
Issue number	22
DOIs	https://doi.org/10.1007/s00018-010-0405-8
State	Published - Nov 2010
Externally published	Yes

Keywords

ATL
Alkyltransferase-like protein
DNA alkylation
DNA base repair
DNA repair
Nucleotide excision repair
O -alkylguanine-DNA alkyltransferase
O -methylguanine-DNA methyltransferase

ASJC Scopus subject areas

Molecular Medicine
Molecular Biology
Pharmacology
Cellular and Molecular Neuroscience
Cell Biology

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10.1007/s00018-010-0405-8

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title = "Alkyltransferase-like proteins: Molecular switches between DNA repair pathways",

abstract = "Alkyltransferase-like proteins (ATLs) play a role in the protection of cells from the biological effects of DNA alkylation damage. Although ATLs share functional motifs with the DNA repair protein and cancer chemotherapy target O 6-alkylguanine-DNA alkyltransferase, they lack the reactive cysteine residue required for alkyltransferase activity, so its mechanism for cell protection was previously unknown. Here we review recent advances in unraveling the enigmatic cellular protection provided by ATLs against the deleterious effects of DNA alkylation damage. We discuss exciting new evidence that ATLs aid in the repair of DNA O 6-alkylguanine lesions through a novel repair cross-talk between DNA-alkylation base damage responses and the DNA nucleotide excision repair pathway.",

keywords = "ATL, Alkyltransferase-like protein, DNA alkylation, DNA base repair, DNA repair, Nucleotide excision repair, O -alkylguanine-DNA alkyltransferase, O -methylguanine-DNA methyltransferase",

author = "Tubbs, {Julie L.} and Tainer, {John A.}",

note = "Funding Information: This work was supported by National Institutes of Health Grant R01CA097209 (J.A.T.) and The Skaggs Institute for Chemical Biology (J.L.T.).",

year = "2010",

month = nov,

doi = "10.1007/s00018-010-0405-8",

language = "English (US)",

volume = "67",

pages = "3749--3762",

journal = "Cellular and Molecular Life Sciences",

issn = "1420-682X",

publisher = "Birkhauser Verlag Basel",

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T1 - Alkyltransferase-like proteins

T2 - Molecular switches between DNA repair pathways

AU - Tubbs, Julie L.

AU - Tainer, John A.

N1 - Funding Information: This work was supported by National Institutes of Health Grant R01CA097209 (J.A.T.) and The Skaggs Institute for Chemical Biology (J.L.T.).

PY - 2010/11

Y1 - 2010/11

N2 - Alkyltransferase-like proteins (ATLs) play a role in the protection of cells from the biological effects of DNA alkylation damage. Although ATLs share functional motifs with the DNA repair protein and cancer chemotherapy target O 6-alkylguanine-DNA alkyltransferase, they lack the reactive cysteine residue required for alkyltransferase activity, so its mechanism for cell protection was previously unknown. Here we review recent advances in unraveling the enigmatic cellular protection provided by ATLs against the deleterious effects of DNA alkylation damage. We discuss exciting new evidence that ATLs aid in the repair of DNA O 6-alkylguanine lesions through a novel repair cross-talk between DNA-alkylation base damage responses and the DNA nucleotide excision repair pathway.

AB - Alkyltransferase-like proteins (ATLs) play a role in the protection of cells from the biological effects of DNA alkylation damage. Although ATLs share functional motifs with the DNA repair protein and cancer chemotherapy target O 6-alkylguanine-DNA alkyltransferase, they lack the reactive cysteine residue required for alkyltransferase activity, so its mechanism for cell protection was previously unknown. Here we review recent advances in unraveling the enigmatic cellular protection provided by ATLs against the deleterious effects of DNA alkylation damage. We discuss exciting new evidence that ATLs aid in the repair of DNA O 6-alkylguanine lesions through a novel repair cross-talk between DNA-alkylation base damage responses and the DNA nucleotide excision repair pathway.

KW - ATL

KW - Alkyltransferase-like protein

KW - DNA alkylation

KW - DNA base repair

KW - DNA repair

KW - Nucleotide excision repair

KW - O -alkylguanine-DNA alkyltransferase

KW - O -methylguanine-DNA methyltransferase

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U2 - 10.1007/s00018-010-0405-8

DO - 10.1007/s00018-010-0405-8

M3 - Review article

C2 - 20502938

AN - SCOPUS:78149464738

SN - 1420-682X

VL - 67

SP - 3749

EP - 3762

JO - Cellular and Molecular Life Sciences

JF - Cellular and Molecular Life Sciences

IS - 22

ER -

Alkyltransferase-like proteins: Molecular switches between DNA repair pathways

Abstract

Keywords

ASJC Scopus subject areas

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