TY - JOUR
T1 - All-cause mortality in patients with basal and squamous cell carcinoma
T2 - A systematic review and meta-analysis
AU - Wehner, Mackenzie R.
AU - Cidre Serrano, Wilmarie
AU - Nosrati, Adi
AU - Schoen, Patrick Michael
AU - Chren, Mary Margaret
AU - Boscardin, John
AU - Linos, Eleni
N1 - Publisher Copyright:
© 2017 American Academy of Dermatology, Inc.
PY - 2018/4
Y1 - 2018/4
N2 - Background: There are varying reports of the association of basal cell carcinoma (BCC) and cutaneous squamous cell carcinoma (SCC) with mortality. Objective: To synthesize the available information on all-cause mortality after a diagnosis of BCC or SCC in the general population. Methods: We searched PubMed (1966-present), Web of Science (1898-present), and Embase (1947-present) and hand-searched to identify additional records. All English articles that reported all-cause mortality in patients with BCC or SCC were eligible. We excluded case reports, case series, and studies in subpopulations of patients. Random effects model meta-analyses were performed separately for BCC and SCC. Results: The searches yielded 6538 articles, and 156 were assessed in a full-text review. Twelve studies met the inclusion criteria, and 4 were included in the meta-analysis (encompassing 464,230 patients with BCC and with 175,849 SCC), yielding summary relative mortalities of 0.92 (95% confidence interval, 0.83-1.02) in BCC and 1.25 (95% confidence interval, 1.17-1.32) in SCC. Limitations: Only a minority of studies controlled for comorbidities. There was significant heterogeneity in meta-analysis (χ2 P <.001, I2 > 98%), but studies of SCC were qualitatively concordant: all showed statistically significant increased relative mortality. Conclusions: We found that patients with SCC are at higher risk for death from any cause compared with the general population.
AB - Background: There are varying reports of the association of basal cell carcinoma (BCC) and cutaneous squamous cell carcinoma (SCC) with mortality. Objective: To synthesize the available information on all-cause mortality after a diagnosis of BCC or SCC in the general population. Methods: We searched PubMed (1966-present), Web of Science (1898-present), and Embase (1947-present) and hand-searched to identify additional records. All English articles that reported all-cause mortality in patients with BCC or SCC were eligible. We excluded case reports, case series, and studies in subpopulations of patients. Random effects model meta-analyses were performed separately for BCC and SCC. Results: The searches yielded 6538 articles, and 156 were assessed in a full-text review. Twelve studies met the inclusion criteria, and 4 were included in the meta-analysis (encompassing 464,230 patients with BCC and with 175,849 SCC), yielding summary relative mortalities of 0.92 (95% confidence interval, 0.83-1.02) in BCC and 1.25 (95% confidence interval, 1.17-1.32) in SCC. Limitations: Only a minority of studies controlled for comorbidities. There was significant heterogeneity in meta-analysis (χ2 P <.001, I2 > 98%), but studies of SCC were qualitatively concordant: all showed statistically significant increased relative mortality. Conclusions: We found that patients with SCC are at higher risk for death from any cause compared with the general population.
KW - all-cause mortality
KW - basal cell carcinoma
KW - cutaneous squamous cell carcinoma
KW - keratinocyte carcinoma
KW - meta-analysis
KW - systematic review
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U2 - 10.1016/j.jaad.2017.11.026
DO - 10.1016/j.jaad.2017.11.026
M3 - Article
C2 - 29146125
AN - SCOPUS:85041903286
SN - 0190-9622
VL - 78
SP - 663-672.e3
JO - Journal of the American Academy of Dermatology
JF - Journal of the American Academy of Dermatology
IS - 4
ER -