TY - JOUR
T1 - Allogeneic bone marrow transplantation for hematological malignancies following etoposide, cyclophosphamide, and fractionated total body irradiation
AU - Yau, Jonathan C.
AU - Huan, Susan D.
AU - Lemaistre, Charles F.
AU - Meneghetti, Carole M.
AU - Andersson, Borje S.
AU - Wallerstein, Ralph O.
AU - Woo, Shiao Y.
AU - Brunner, Lane J.
AU - Dimopoulos, Meletios A.
AU - Jagannath, Sundar
AU - Deisseroth, Albert B.
AU - Spitzer, Gary
AU - Spencer, Verneeda
AU - Spinolo, Jorge A.
AU - Dicke, Karel A.
AU - Giralt, Sergio
PY - 1992/9
Y1 - 1992/9
N2 - Forty‐three patients received etoposide, cyclophosphamide, and fractionated total body irradiation before allogeneic marrow transplantation. Fifteen patients had chronic myelogenous leukemia in chronic phase or acute leukemia in first remission (standard risk) and twenty‐eight patients with more advanced disease (high risk). All patients received etoposide 1,500 mg/m2 intravenously on day –8, cyclophosphamide 60 mg/kg/day intravenously on days –7 and –6, and total body irradiation at 170 cGy twice a day on days –3, –2, and –1. During the first 100 days 12 high risk patients (43%) died from causes unrelated to relapse while none of the standard risk patients died. Renal and hepatic dysfunction were also significantly increased during the first 14 days in the high risk group. The addition of 1,500 mg/m2 of etoposide to the cyclophosphamide and total body irradiation was well tolerated for patients with standard risk. However, the regimen was poorly tolerated with high mortality in patients with more advanced disease. © 1992 Wiley‐Liss, Inc.
AB - Forty‐three patients received etoposide, cyclophosphamide, and fractionated total body irradiation before allogeneic marrow transplantation. Fifteen patients had chronic myelogenous leukemia in chronic phase or acute leukemia in first remission (standard risk) and twenty‐eight patients with more advanced disease (high risk). All patients received etoposide 1,500 mg/m2 intravenously on day –8, cyclophosphamide 60 mg/kg/day intravenously on days –7 and –6, and total body irradiation at 170 cGy twice a day on days –3, –2, and –1. During the first 100 days 12 high risk patients (43%) died from causes unrelated to relapse while none of the standard risk patients died. Renal and hepatic dysfunction were also significantly increased during the first 14 days in the high risk group. The addition of 1,500 mg/m2 of etoposide to the cyclophosphamide and total body irradiation was well tolerated for patients with standard risk. However, the regimen was poorly tolerated with high mortality in patients with more advanced disease. © 1992 Wiley‐Liss, Inc.
KW - allogeneic
KW - cyclophosphamide
KW - etoposide
KW - transplantation
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U2 - 10.1002/ajh.2830410108
DO - 10.1002/ajh.2830410108
M3 - Article
C2 - 1503097
AN - SCOPUS:0026666067
SN - 0361-8609
VL - 41
SP - 40
EP - 44
JO - American journal of hematology
JF - American journal of hematology
IS - 1
ER -